الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Inflammatory bowel disease (IBD) is a chronic idiopathic
disease affecting the gastrointestinal tract that is comprised of two
separate, but related intestinal disorders; Crohn’s disease (CD)
and ulcerative colitis (UC). The diagnosis of IBD is most
commonly made on the basis of clinical features mentioned above
in combination with findings on ultrasonography, endoscopy and
histopathology.
Apart from endoscopic interventions, readily attainable costeffective
biomarkers for IBD assessment are required.
The NLR is a cost-effective, common, and simple biomarker.
According to recent studies, the NLR may be a new promising
marker of the disease severity in IBD. However, the data on NLR
and its association with other inflammatory serum markers are not
convincing. Therefore, in the present study, we aimed to evaluate
the NLR as simple rapid and cheap test readily available for
assessment of severity of IBD findings of ultrasonography and
colonoscopy.
This is a cross-sectional prospective observational study.
This study included 40 IBD patients (19 females and 21 males),
presented to Internal Medicine department, El-Demerdash
Hospital, Ain Shams University from June 2018 to June 2019.
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Patients were matched with 10 healthy subjects (7 females and 3
males) as a control group.
The diagnosis of IBD was established based on previous
endoscopic, clinical, and pathological features. Furthermore, 10
healthy individuals who had no IBD based on their previous
colonoscopy reports were included as a control group.
All patients subjected to the following: Thorough medical
history, clinical examination (general and local) and laboratory
investigations including complete blood count with calculation of
neutrophils to lymphocyte ratio, ESR and CRP on the day of the
colonoscopic procedure. US examination and endoscopic
examination were done for every patient.
Statsitical analysis of our findings revealed following
data:
Mean value of NLR in IBD patients was significantly
higher than those in control group representing 3.12±1.87 and
1.88±0.42 respectively but it was statisitically insignificant
between active and inactive IBD patients with best cut off >2,01
to differentiate active from inactive patient.THE NLR value was
correllating with CRP only with no correlation with ESR,NLR
value also has association with US findings that suggesting
activity with best cut off >2.5 to detect these findings by US in
active patients.US has high sensitivity and specificity in
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discriminating patients with moderate and severe activity from
those with mild activity or those in remission but it was unable to
discriminate patient of moderate activity from patients with severe
activity with strong assossiation with endoscopic scores of activity