الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 144 |  |  |
| | | from | 144 | | |
Abstract
Pantoprazole a proton pump inhibitor which is a benzimidazole derivative, it is a pro-drug that after administration must be activated in acidic environment. It suppresses the final step in gastric acid production by forming a covalent disulfide bond with cysteine in two sites of (H + K + adenosine triphosphatase) enzyme system at the secretory surface of the gastric parietal cells. This effect leads to inhibition of both basal and stimulated gastric acid secretion. So it can be used for treatment of various acid peptic disorders including GERD, Peptic ulcer, non-steroidal anti- inflammatory drug induced gastropathy and associated with antibiotic for Helicobacter Pylori eradication.
The present study was conducted to throw light on the adverse effects of Pantoprazole and the protective effect of vit. E and to show the result of the combination between pantoprazole and vit.E on renal toxicity and hepatotoxicity which may occur by using Pantoprazole in rats.
Experimental design:
After one week of acclimatization, eighty albino rats randomly were allocated into 4 equal groups, each group contain 20 rats.
First group (Control): rats in this group were not medicated and left as a control and received saline as a vehicle.
Second group (Vitamin E): rats in this group received a repeated oral doses of vit .E (100 mg /kg, P.O. once daily) for successive 21 days as standard antioxidant.
Third group (Pantoprazole): rats in this group received a repeated oral doses of pantoprazole (3.6 mg/kg, P.O. once daily) for successive 21 days.