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العنوان
Comparison between Corticosteroids and Antifungal Drugs in Treatment of Allergic Fungal Rhinosinusitis /
المؤلف
El-Shamy, May Mohamed El-Hasan Ibrahim.
هيئة الاعداد
باحث / مي محمد الحسن ابراهيم الشامي
مشرف / محمد عبد الرؤوف مسعود
مشرف / أنس محمد عسكورة
تاريخ النشر
2019.
عدد الصفحات
86 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب (متفرقات)
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية الطب - الانف والاذن والحنجرة
الفهرس
Only 14 pages are availabe for public view

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from 86

Abstract

AFRS has been defined as a localized allergic (eosinophilic) inflammatory disease of sinuses, resulting in accumulation of the eosinophilic (allergic mucin), containing intense eosinophilic inflammation, fungal hyphae and characteristic radiographic findings.
Diagnosis is beginning with the clinical history, Bent and Kuhn have published in 1994 the diagnostic criteria based on histologic, immunologic and radiologic characteristics of that disease and characteristic findings of CT scan.
AFRS treatment has been including FESS as a first line, corticosteroids and antifungal drugs have been given to prevent recurrence after surgery, also have been used as treatment before surgery.
In this meta-analysis, 3 articles were included with a total number of participants (144) patients and all have been published between 2015 and 2006.
The research studies were documented no statistical significant difference between antifungals and steroids in AFRS treatment with Cochran Q = 1.554, df = 1, p-value = 0.213, I-squared = 35.648. (FEM: odds ratio = 0.50, 95% CI (confidence limits) = 0.21 to 1.17, p-value = 0.11) according to Kupferberg grade I-III.
In addition, with odds ratio = 0.37, 95% CI = 0.10 to 1.45, p-value = 0.15 according to recurrence.