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العنوان
Platelet-rich Plasma Role in
Bone Tumors Defects /
المؤلف
Emara, Mohamed Gad Mohamed.
هيئة الاعداد
مشرف / Mohamed Abdel Rahman Mostafa
مناقش / Sherif Ishak Azmy
باحث / Mohamed Gad Mohamed Emara
مشرف / Sherif Ishak Azmy
تاريخ النشر
2019.
عدد الصفحات
95p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب (متفرقات)
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية الطب - العظام
الفهرس
Only 14 pages are availabe for public view

from 95

from 95

Abstract

Summary
n activation, platelets secrete an array of growth factors
that contribute to bone regeneration. Combining plateletrich
plasma (PRP) with bone graft substitutes has the potential
to reduce or replace the reliance on auto-grafts. Lack of
standardization and improper use may contribute to the
conflicting outcomes reported within both preclinical and
clinical investigations using PRP. This study investigates the
effect of PRP dose on bone augmentation.
Bone grafting is an essential surgical tool for the
augmentation of bone defects; Autogenous bone graft remains
the most reliable treatment option due to its ability to provide
an osteo-conductive matrix, osteo-inductive factors, and
osteogenic properties. However, in addition to the limited
supply, the harvesting of auto-graft has been associated with a
high rate of complications.
Platelets release a variety of signalling molecules that
orchestrate bone healing. The basis of platelet-rich plasma
(PRP) relies on the ability to concentrate and activate platelets,
and to deliver a supra-physiologic concentration of the released
growth factors to a defect site.
The present study evaluated the efficacy of activated PRP
combined with a biphasic calcium phosphate (BCP) to treat
established critical-sized cancellous bone defects on bone tumors