الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Several pyrazine derivatives were found to possess antimycobacterial activity. Pyrazinamide is one of the most important first-line drugs used in TB-therapy.
Due to its simple structure, it provides a good opportunity for further structural modification aiming to increase its antimycobacterial activity.
The interesting and unique properties of pyrazinamide and/or its derivatives (sterilizing activity and multiple mechanisms of action) motivated us to explore novel lead structures as potent anti-tubercular agents. Thus, our present investigation was focused on design, synthesis and investigation of a new series of pyrazine derivatives.The present study was initiated to synthesize a series of hybrid molecules containing pyrazine moiety linked at position-2 to several bioactive heterocyclic moieties with differentatoms spacer.
In addition, another series of hybrid molecules were designed by directly attaching bioactive heterocycles to the pyrazine nucleus in order to investigate the effect of such modification on the anticipated biological activity.