الفهرس | Only 14 pages are availabe for public view |
Abstract S ince infertility represents a major physiological and psychological problem to a growing proportion of the population, governments worldwide are investing heavily in assisted reproductive technology (ART) which has led to significant improvements in our understanding of male/female reproductive systems, gamete preservation and gamete manipulation. ART now accounts for 7% of all births in some developed countries. Worldwide, ~1 million ART treatments are performed each year and over 8 million ART babies have been born worldwide. Progesterone (P) and e is required for successful conception, to prepare the endometrium for blastocyst implantation and pregnancy. During ICSI cycles, the endometrium and embryo are exposed to supra-physiological concentrations of progesterone during ovarian stimulation, which could influence pregnancy outcomes. This study analysed the relationship between ratio of serum progesterone to number of follicles on the day of HCG administration in ICSI cycle and pregnancy rate in gonadotrophin-releasing hormone agonist protocols. The study was conducted in Ain Shams University Maternity Hospital, in ART unit, included 100 patients underwent ICSI as a treatment of infertility. We reported that weight, BMI, duration of infertility, and number of embryo transfered were higher in non-pregnant females than pregnant one. The results of our study analysis did not detect any statistically significant difference among the two groups of patients as regard all the parameters of the outcome including dose and drug used for stimulation, number of oocytes retrieved& fertilized oocyte. Also we found that pregnant cases had a lower ratio of progesterone to number of follicles compared to non pregnant cases with significant difference. Our findings need to be confirmed in future studies with larger sample of patients. |