الفهرس 
helicobacter pyloriOnly 14 pages are availabe for public view
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Abstract
Chronic Helicobacter pylori infection may persist for years and cause changes in the gastric mucosa, leading to duodenal ulcer, gastric ulcer, gastric cancer, or mucosa-associated lymphoid tissue lymphoma.
Many noninvasive and invasive methods have been developed for the diagnosis of H. pylori infections. Invasive methods include culture, histology, rapid urease testing or polymerase chain reaction (PCR) bacterial DNA amplification and are based on upper gastrointestinal endoscopy with biopsy. Non invasive methods include the use of H. pylori-specific antibodies, the urea breath test (UBT) using 13C- or 14C-labeled urea, and stool antigen detection.
Chromoendoscopy or tissue staining is an “old” endoscopic technique that has been used for decades. It involves the topical application of stains or pigments to improve localization, characterization, or diagnosis. Red phenol staining has been used to detect and map the distribution of H pylori.The aim of this study was to investigate the value of red phenol chromoendoscopy in gastric H.pylori diagnosis in comparison to histopathology as gold standard.
This study was carried on 80 adult patients with dyspepsia and underwent upper gastrointestinal endoscopy with biopsy. Patients on antisecretory treatment up to one month before the endoscopic study, those on H. pylori eradication therapy up to 6 months before the test or Patients with gastric surgery, were excluded
The study included 38 male patients (47.5%) and 42 female patients (52.5%). Patients age ranged between 18-56 years with mean age 35.8±8 years. According to histopathological examination, 71 (88.75%) patients were h pylori positive while 9 (11.25%) patients were negative.Red phenol chromoendoscopy examination revealed that 65 patients (81.3%) were positive for h pylori, while 15 patients (18.8%) were negative. We found that red phenol chromoendoscopy test is a valid test for diagnosis of H. pylori infection with 90% sensitivity, 88.9% Specificity, 90% accuracy and positive predictive value (PPV) of 98.4% but with low negative predictive value (NPV= 53.3%).So red phenol chromoendoscopy is a useful method with multiple advantages : fast and immediate reading, and can be used in patients with contraindications for the taking of biopsy samples (coagulation disorders) or can direct the biopsy taking in conditions with focal and scattered infection and in combination to other methods to improve their performance.