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العنوان
Relationship Between Homocysteine, Coronary Risk
Factors, C‐Reactive Protein, Bone Mineral Density and
Carotid Circulation Among frail elderly /
المؤلف
ELMALEH,DEENA MOSTAFA MOHAMED HELMY.
هيئة الاعداد
باحث / DEENA MOSTAFA MOHAMED HELMY ELMALEH
مشرف / MOATASSEM SALAH AMER
مشرف / OMAR HUSSEIN OMAR
مشرف / RANDA ABDEL WAHAB REDA MABROUK
تاريخ النشر
2014
عدد الصفحات
120p.:
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
طب الشيخوخة وعلم الشيخوخة
تاريخ الإجازة
1/1/2014
مكان الإجازة
جامعة عين شمس - كلية الطب - طب وصحة المسنين
الفهرس
Only 14 pages are availabe for public view

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Abstract

Frailty is a rather new concept in geriatric research and
practice. Over the last decades, there has been an exponential
rise in the use of the term “frailty” in the literature. Frail older
people are at high risk for developing adverse outcomes as
disability, morbidity, mortality, hospitalization and
institutionalization. Frailty confers loss of independence and
impairs the quality of life and psychological well-being of older
people. It also poses challenges on families, caregivers, and
other structures of social care and support.
Given the prominent role of CVD in the aggregate
burden of morbidity and mortality in the elderly, it was not
surprising that CVD, was strongly correlated with frailty.
The Women’s Health Initiative Observational Study
showed that community-dwelling older women with CVD and
cardiovascular risk factors were at higher risk of developing
incident frailty. Coronary artery disease and stroke were
associated with the highest risk of developing incident frailty.
Osteoporosis often accompanies advanced frailty and
any fragility fracture in this population is likely to have a profound impact on quality of life and may lead to permanent
disability and even premature death. The multidimensional
aspects of osteoporosis require a multidisciplinary integrated
approach, including environmental, lifestyle, dietary and
pharmacological interventions .
This study was conducted to compare frail &
healthy elderly regarding Bone mineral density, carotid
circulation and serum levels of Homocysteine, coronary risk
factors and CRP.
This study is a case-control study performed on 104
elderly 60 years and older, male and female. They were divided
into two groups:
group A (case group): 52 frail elderly diagnosed by
Fried’s criteria as applied by Avila-Funes et al., 2008.
group B (control group): 52 healthy elderly .
Both groups were recruited from out patient clinics & inpatient
wards at Ain Shams University hospital.
The 104 elderly were subjected to comprehensive
geriatric assessment including personal history, past medical
history, cognitive assessment using mini mental state examination
(MMSE), depression assessment using geriatric depression scale (GDS), functional assessment using the activities and
instrumental activities of daily living (ADL & IADL),
measurment of serum level of : CRP, homocystiene , lipid prfile
(total cholesterol, triglycerides, LDL, HDL), carotid duplex to
assess CIMT, bone DEXA scan to assess spinal & femoral
BMD.
This study showed that frailty has been associated with
higher number of chronic diseases & with specific disease as
DM, hypertension ischemic heart disease,stroke , thyroid
disorders, hearing & visual impairment.Also spinal & femoral
osteoprosis & osteopinea were greater among cases
The study also showed that frail cases had more ADL &
IADL depedance , increased prevelance of depression &
cognitive impairment.
Finally, it was found that patients had higher mean level
of homocystiene,CRP & triglycerides in addition to low serum
HDL & higher CIMT. Homocystiene is more sensitive in
predicting frailty than CRP.