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العنوان
Histopathological Study and Registry of
Tumors and Tumor-like Lesions of the Ear
at Ain-Shams University Hospitals in years
(٢٠٠١-٢٠١٠) /
المؤلف
Nagi,Mona Youssif Hassan.
هيئة الاعداد
باحث / Mona Youssif Hassan Nagi
مشرف / Nedal Ahmed El-said Hegazy
مشرف / Faten Wagdy Ragheb
مشرف / Nehal Ahmed Radwan
تاريخ النشر
2014
عدد الصفحات
203p.:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأورام
تاريخ الإجازة
1/1/2014
مكان الإجازة
جامعة عين شمس - كلية الطب - الباثولوجى
الفهرس
Only 14 pages are availabe for public view

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Abstract

The aim of this work was hospital based registration
and histopathological study of all cases of tumors and
tumor-like lesions of the ear received at the pathology
department, Ain-Shams University Hospital and Ain-
Shams University Specialized Hospital during a period of
١٠ years (٢٠٠١-٢٠١٠). Re-examination of all available
haematoxylin and eosin stained and immunostained slides
was performed to verify histopathological diagnosis.
Statistical analysis of the clinicopathological data extracted
from files and clinical parameters were also done.
The cases of the study were registered as regards the
histopathological diagnosis and available clinical data as
well as age, sex, site and behavior collected from files of
the patients.
The results of this registry study revealed that
tumors and tumor-like lesions of the ear diagnosed during
the period from January ٢٠٠١ to December ٢٠١٠ at the
pathology department of Ain Shams University Hospital
and Ain Shams University Specialized Hospital were ٨٥
cases. The highest percentage of referred cases was in year (١٧٫٦٪) followed by ٢٠٠٣ (١٤٫١٪) and ٢٠١٠
(١١٫٨٪).
The male cases were ٥١ cases (٦٠٪), while the
female cases were ٣٤ cases (٤٠٪), with male to female ratio
(٣:٢).
The age of cases ranged from ١٤ to ٨٤ years old. The
mean age was ٤٩٫٤ with standard deviation (SD) = ١٧٫٣
with no significant difference in the mean age between
males and females, and the median age was ٥٢ years.
The most common site of tumors and tumor-like
lesions of the ear was the external ear. Out of ٨٥ cases, ٥٤
cases (٦٣٫٥ %) arose from the external ear and ٣٠ cases
(٣٥٫٣ %) arose from the middle ear. A higher percentage of
external ear lesions among males (٧٨٫٤٪) compared to
(٤١٫٢٪) among females, whereas, a higher percentage of
middle ear lesions among females (٥٨٫٨٪) compared to
(١٩٫٦٪) among males and the difference was highly
significant statistically (P<٠٫٠١).
The majority of ear lesions arose from the skin and
subcutaneous tissue (٥١٫٨ %) followed by lesions of neural
or ganglion origin (٢٨٫٣ %). The skin &SC tissue were the
major origins of lesions among males (٥٨٫٨ %) while
lesions of neural or ganglion origin were higher among females (٥٢٫٩ %) and the difference was highly significant
statistically (P<٠٫٠١).
Out of the ٨٥ cases, tumors represented (٩١٫٨ %) of
cases and tumor-like lesions were (٨٫٢ %). A higher
percentage of tumors was found among females (٩٤٫١٪)
compared to (٩٠٫٢٪) among males, while a higher
percentage of tumor-like lesions was found among males
(٩٫٨٪) compared to (٥٫٩٪) among females but the
difference was not significant statistically (P>٠٫٠٥).
The most common histopathological type of lesion
was paraganglioma (٢٧٫١ %) followed by squamous cell
carcinoma (٢٥٫٩ %) then twelve cases (١٤.١ %) were
osteoma and seven cases (٨٫٢٪) were keratotic skin lesions.
Only ٢ cases (٢٫٤ %) were basal cell carcinoma and ٢
cases (٢٫٤ %) were the so-called middle ear adenoma and
carcinoid tumor. Only one case of metastasis from
mucoepidermoid carcinoma of parotid. A higher percentage
of squamous cell carcinoma was found among males
(٣٣٫٣٪) compared to (١٤٫٧٪) among females and higher
percentage of osteoma was detected among males (٢١٫٦٪)
compared to (٢٫٩٪) among females. A higher percentage of
paraganglioma among females (٥٢٫٩٪) compared to (٩٫٨٪)
among males and the difference is highly significant
statistically. A higher percentage of squamous cell carcinoma among older age group subjects, while there was
a higher percentage of keratotic skin lesions among
younger age group but the difference was not significant
statistically(P<٠٫٠١).
Only ٣٢٫٩ % of all cases were malignant tumors.
There was a higher percentage of malignant behavior
among older age group patients >٥٢ years (٤٥٪) compared
to (٢٢٫٢٪) among younger age group ≤٥٢ years and the
difference was significant statistically (P<٠٫٠٥). A higher
percentage of malignant behavior was found among males
compared to females but the difference was not significant
statistically.
In addition, cases were divided according to year of
collection into group I including cases collected from ٢٠٠١
to ٢٠٠٥ and group II including cases from ٢٠٠٦ to ٢٠١٠. A
higher percentage of malignant behavior among group II
compared to group I but the difference was not significant
statistically (P>٠٫٠٥). Malignant ear tumors of year group I
(٢٠٠١-٢٠٠٥) represented ٠٫١٦% of total malignant tumors
diagnosed during the same period. Also, non-melanoma
skin cancer diagnosed in the ear during year group I
constituted ٥٫١٢ % of total non-melanoma skin cancer
diagnosed during the same period.