الفهرس 
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Abstract
Unbalanced exposure to environmental endocrine disruptor compounds during fetal or neonatal life evoked disruption in endocrine function during development. Triclosan and butylparaben are widely used as preservatives and it was reported to have estrogenic activity as EDC. The aim of current study is to address the potential impacts of individual or combined administration of triclosan , butyl paraben on the gonadal hormone and potential combined toxicity representing oxidative stress induction in testicular tissue in weanling male rats. Weanling male rats were orally administered individual or combined butylparaben, triclosan (50 mg kg-1day-1) for 4weeks and 8 weeks, followed by determining the serum gonadal hormones, oxidative stress parameters and DNA damage using comet assay in testicular tissues. Results revealed that treated groups compared to control groups caused significant depletion in count and motility of sperm, the relative weight of (SATs) Sex accessories tissue, and levels of (T), (LH), (FSH), T/E2 and T/LH. Alongside, individual treatment significantly increases (E2¬) levels, whereas combined treatment non-significantly decreased its level. All treated groups did not alter the mean differences of both right and left testis relative weights. A significant elevation in oxidative parameters and an obvious testicular DNA damage was recorded. Moreover, a disturbance of antioxidant parameters in all treated groups was observed. Our results revealed that combined treatment aroused an endocrine disturbance activity with a concomitant induction of testicular oxidative stress status which may represent a common mechanism in an endocrine disruptor-mediated dysfunction.