الفهرس 
Radiobiological Basics for HypofractionationOnly 14 pages are availabe for public view
Abstract
ABSTRACT
Our study revealed that Hypofractionated adjuvant radiotherapy in node positive breast cancer patients is equivalent to conventional fractionation, in disease free survival, cosmetic outcome and arm lymphoedema, with decreased early skin reactions; the DFS was 32.4&36.2 months in conventional and hypofractionated arms respectively, (p:0.6),no statistical significant difference in the excellent/good cosmetic score; 46.2%&71.4% in patient scoring respectively (p:0.182), 8%&29% in doctor scoring (p:0.32) respectively, the prevalence of arm lymphoedema was 40% & 22.2% respectively (p:0.149), while hypofractionated radiotherapy significantly lower the incidence of dry desquamation 28.1% in comparison to conventional fractionation 52.9% (p:0.04), with border line significant lowering of skin darkness (p:0.054), but insignificantly lower wet desquamation (p:0.601).
These results are consistent with the results of the main randomized trials comparing hypofractionation radiotherapy versus conventional fractionation in breast cancer, proving that they are equally effective as regard the loco-regional control, systemic metastasis, overall survival, excellent/good cosmetic outcome, radiation induced pneumonitis, ischemic heart disease and radiation predisposed rib fraction, with lower costs and better quality of life; making hypofractionation a preferred choice for early breast cancer management.
Keywords: Radiation Induced Brachial Plexopathy - Regional Nodal Irradiation - Tumor Control Probability