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Lichen planus (LP) is an inflammatory autoimmune disease of unknown etiology but cell-mediated immune dysfunction is implicated in the disease’s complex etiopathogenesis. The inflammatory processes and cytokines released in LP could potentially explain the link between LP and dyslipidemia and possibly other components of the metabolic syndrome.
In this research serum blood samples were obtained from 30 LP patients. Thirty age and sex matched normal individuals were included as a control group consisting of 15 healthy control and 15 matched control (having other minor cutaneous lesions).
Our results showed statistically significant differences between cases and controls as regards the lipid profiles, there were higher levels of low density lipoprotein (LDL), triglyceride (TG), cholesterol (CHOL) and lower level of high density lipoprotein (HDL) among LP patients compared to the control group.
No significant difference was found between men and women with lichen planus regarding dyslipidemia with the exception of triglyceride, which was higher in males compared to females.This is likely due to greater insulin resistance among male.There were no statistically significant differences among the cases and controls as regards age, sex, diabetes mellitus and smoking.
Lipid levels screening in males or females with lichen planus may be useful to detect individuals at risk and start preventive treatment against the development of cardiovascular disease.