Only 14 pages are availabe for public view
HCV is a major health problem, it is the main cause of
transfusion-associated hepatitis and is also seen in intravenous
drug abuse, organ transplant and hemodialysis patients and
health care workers. In addition to hepatitis, cirrhosis and HCC,
several extra-hepatic manifestations have been reported in the
natural history of HCV infection. According to different studies,
40-74% of patients infected with HCV might develop at least
one EHM during the course of the disease.
A significant proportion of these extrahepatic
manifestations disorders involve the skin. Various cutaneous
eruptions have been described in the setting of HCV infection.
Urticaria is a common disorder that affects up to 20% of the
population at some points during their lifetime. Aggravating
factors include drugs, foods, additives, connective tissue
disorders and infections. It is well established that HBV causes
urticaria. Whether Hepatitis C infection causes urticaria or not
is still debated with reports both in favor of and against this.
The aim of this study was to analyze the frequency of
urticaria in chronic renal dialysis Egyptian patients with HCV
This study was performed on 100 CKD patients on
regular renal HD and they were divided into two groups: Group
I: consists of 50 patients with CKD and positive for anti-HCV
antibodies. group II: consists of 50 patients with CKD and
negative for anti-HCV antibodies. Besides the third group
consists of 50 healthy individuals with negative anti-HCV antibody and served as control group. Full patient assessment was done for all groups including
thorough history taking, physical examinations, skin prick test and some hematological
We found that:-
Seventy sex percent of CKD patients acquire HCV
infection before the onset of dialysis.
The prevalence of skin lesions was approximately similar in CKD patients with HCV positive
antibodies or HCV negative antibodies.
The majority of CKD patients with positive HCV
suffered from pruritis only.
The frequency of urticaria among CKD patients with negative HCV was higher than those with
Positive SPT test was significantly higher in CKD
patients with negative HCV group than those in the CKD
with positive HCV groups and control group.