الفهرس | Only 14 pages are availabe for public view |
Abstract A significant increase in the incidence of male osteoprosis has been described, about 20 % of which have unknown etiology, it may be attributable to environmental exposures. The aim of this study is to determine the environmental exposure to cadmium as a cause of male osteoprosis and to find out its effect on bone density. The current study included 120 males with age ranging from 27-55 years, they were divided into: GroupI: 80 male patients, subdivided into: Subgroup Ia: smokers with osteoporosis (40 patients). Subgroup Ib: Non-smokers with variable changes in bone density group II: 40 healthy males as controls. Both groups were subjected to full history taking and examination, laboratory investigations including kidney functions, Serum Calcium , phosphorus & alkaline phosphatase, estimation of cadmium levels in blood. The results were statistically analyzed and we observed that blood cadmium levels were higher in the Osteoporotic male smokers compared to the non smokers & controls and it was positively correlated with Smoking index. Osteoprosis was found to be significantly higher in the male smokers compared to the controls, Calcium , phosphorus and ALP showed statistically significant difference between patients and controls. Cadmium had a significant inverse relationship with male smoker bone density. Neither the age nor the BMI had a significant correlation with cadmium or DEXA results. There is a statistically highly significant positive correlation between serum urea & creatinine levels & osteoporosis , There is also significant positive correlation with both & osteopenia . |