الفهرس | Only 14 pages are availabe for public view |
Abstract Overweight and obesity are subjects of much public health concern especially among children and adolescents in different regions of the world . Childhood obesity predisposes to type 2 diabetes , hypertension , hyperlipidemia , hepatic and renal diseases and cardiovascular diseases .Hyperuricemia is one of the laboratory abnormalities often seen in pediatric clinics. Recently, greater attention has been focused on Hyperuricemia in children, since several investigators reported its association with life-style diseases .Some studies have reported the incidence of hyperuricemia in obese children. The aim of the study was to establish a relationship between serum uric acid and weight in Egyptian adolescents . This study was conducted on 60 apparently healthy early adolescent children aged 12-14 years , they have been divided into three equal groups according to body mass index for age percentiles obese adolescents , overweight adolescent and normal weight adolescents . They were subjected to full medical history, thorough clinical examination, laboratory investigation (including serum uric acid and ALT) in addition to anthropometric measurements which include weight, height, body mass index , waist circumference and hip circumference .Our results showed that there was a statistically significant difference between the three groups of adolescents as regards the mean value of serum uric acid as the obese and overweight adolescents showed higher level of serum uric acid than the normal weight adolescents .And there was a statistically significant positive correlation between serum uric acid and waist circumference and a high statistically significant positive correlation between serum uric acid and weight , BMI and hip circumference . The use of the multiple logistic regression test to show predictors of hyperuricemia revealed a significance of the use of waist circumference , hip circumference and waist to hip circumference as predictors of hyperuricemia in adolescents and the waist circumference was the best predictor of hyperuricemia with sensitivity 76.4 % , specificity 74.4 % and Cut-off point = 91.50 . |