الفهرس 
INTRODUCTION AND REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
P
eriodontal disease is a common oral disease that is identified by severe inflammation and loss of the periodontal attachment apparatus. Regenerative periodontal therapy aims to restore the tooth’s supporting periodontal tissues that have been lost due to periodontal disease.
The objective of the present study is to evaluate the effect of EDTA root surface etching on simvastatin and curcumin availability in the GCF and to evaluate the influence of EDTA-curcumin-simvastatin on the clinical and radiographic outcome of the surgical treatment of intrabony periodontal defect.
Demineralization of root surface with 24% EDTA removes smear layer and exposes collagen fibers. Simvastatin exerts anabolic effects on bone beside its anti-resorptive actions. Moreover, it has anti-inflammatory and antimicrobial properties. Curcumin enhances wound healing and it has anti-inflammatory, antioxidant, and antimicrobial effects.
The present study entailed thirty patients having stage II or stage III, Grade A periodontitis with 30 intrabony defects. Patients were divided into three groups; group I was subjected to open flap debridement only. group II was subjected to open flap debridement followed by application of curcumin-simvastatin paste (2%curcumin and 1.2 %simvastatin). While group III was subjected to open flap debridement followed by 24% EDTA root surface etching and application of curcumin-simvastatin paste (2%curcumin and 1.2% simvastatin).
Clinical parameters including plaque index, sulcus bleeding index, probing depth and clinical attachment level were recorded presurgical. Moreover, Radiographic examination was performed by CBCT before the surgery by 1 week. Vertical bone defects were exposed by full thickness mucoperiosteal flap following intrasulcular incision and thorough debridement was performed. group II received local application of simvastatin-curcumin paste. group III received local application of simvastatin-curcumin paste was performed after debridement and 24 % EDTA root surface etching.
The same initial clinical parameters were recorded three and six months postoperatively. Radiographic measurements were recorded six months post surgically.
Our results showed no statistically significant difference in mean sulcus bleeding index and plaque index in different observation times in the three groups. In the intervals from baseline to 3 months, and from baseline to 6 months, group II and III recorded more reduction in PD and more gain in CAL compared to group I, and this was statistically significant. While there was no significant difference between group II and group III in PD reduction and CAL gain.
Regarding curcumin and simvastatin availability, group III showed statistically significantly higher mean curcumin and simvastatin concentration than group II.
Radiographic examination from baseline to 6 months showed a statistically significant bone fill in group II and III compared to group I. While there was no statistically significant difference in bone fill between groups II and III.