الفهرس 
HEPATITIS A VIRUSOnly 14 pages are availabe for public view
Abstract
This study was conducted in 4 weeks duration on 50 children and adolescents with acute hepatitis A infection treated with traditional therapy divided into two groups each group included 25 patients.
group A (Intervention group) included 25 patients who received a calculated daily dose of honey 3ml/kg/day for 4 weeks to explore the effect of its intake on clinical outcome and laboratory liver function tests .
group B (Non-Intervention group) included 25 patients who did not receive honey for the 4 weeks of the study to examine whether the change was due to honey ingestion or not.
The patients were recruited from the regular attendants of the children in the out-patients Pediatric Clinic of Ain Shams University Hospital.
All patients were subjected to:
1. Full history taking including time of illness.
2. Data from each patient’s file was accurately recorded as regards there is another chronic diseases.
3. Honey was given in a daily oral dose of 3 ml/kg for 4 weeks according to the protocol of each group.
4. Thorough clinical examination.
5. Follow up procedures were performed at enrollment, 2weeks and 4 weeks of the study including:
• clinical assessment to every patient: (vital signs, fever, vomiting, liver tenderness, jaundice, dark urine, light colored stool, constipation, diarrhea, decreased appetite and splenomegally).
• Lab finding: (AST, ALT, GGT, TOTAL BILLRUBIN and DIRECT BILLRUBIN). At week 0, week 2 and week 4 .
And we found that:
Our study included 50 patients (24male, 26 female) with acute hepatitis A infection. They were divided into 2 groups, the Intervention group (group 1) and the non intervention group- (group 2). On comparing baseline studied variables between them, there were no statistical significant differences as regard baseline characteristics of patients.
There were statistically decrease in number of patients with decreased appetite in intervention group compared to non intervention group at week 2.
Study show that liver tenderness, jaundice and low grade fever statistically lowered in intervention group at week2.
Study show that: no statistical significant difference between symptoms (decrease appetite, jaundice, low grade fever) in non intervention group (same group) between week 0 and week2, while there is significant decrease in symptoms (decrease appetite, jaundice, low grade fever) in intervention group (same group) between week 0 and week2.
There is statistical significant decrease during week 2 in liver enzyme AST and total and direct billrubin in intervention group compared to non intervention group .
There is statistical significant decrease during week 4 in total and direct billrubin, AST, ALT&GGT liver enzymes in intervention group compared to non intervention group with p < 0.005 .
Study show that : There is statistical significant decrease in percent % of decrease in liver enzyme (AST) between week 0 to week 2 time in intervention group compared to non intervention group with p<0.005 .
There is statistical significant decrease in percent % of decrease in total billrubin between week 0 to week 2 time in intervention group compared to non intervention group with p<0.005.
There is statistical significant decrease in percent % of decrease in direct billrubin between week 0 to week 2 time in intervention group compared to non intervention group with p<0.005.
There is statistical significant decrease in percent % of decrease in liver enzyme (ALT) between week 0 to week 4 time in intervention group compared to non intervention group with p<0.005 .
There was no statistical significant difference between 2 groups at duration of illness.
There is statistical significant decrease at recovery time in intervention group compared to non intervention group with p = .000.