الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Autoimmune disorders are considered one of the most important clinical manifestations in patients with SIgAD. The prevalence of autoimmunity in SIgAD individuals has been shown to be highly variable, ranging from 7%to 36% in symptomatic SIgAD individuals.
Some autoimmune diseases including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, T1DM, rheumatoid arthritis, thyroiditis, systemic lupus erythematosus and CD are more common in SIgAD patients.
The association between T1DM and SIgAD has been recognized in many populations, a high prevalence of SIgAD has been found in several studies of children and adults with T1DM, its prevalence rates are estimated to be between 0.4% and 5.4% which is more than 10 times the prevalence in the general population.
The aim of this study was to measure IgA level in serum among patients with T1DM as compared to healthy controls.
The present study is a case control study conducted on two groups:
group I: 50 T1DM patients recruited from endocrinology clinic of Ain Shams University
group II: 50 healthy control subjects of comparable age and sex.
A detailed history was taken from each subject to fulfill the following data age, sex, age of onset of DM, control of DM, associated other autoimmune disease. FBG, 2h PG, HbA1c, sIgA, sIgM and sIgG were obtained. Eighteen subjects were excluded as they had low sIgG and /or sIgM levels.
Our study showed that there is a higher prevalence of SIgAD among cases group (60.0%) in comparison to control group (0.0%). Which demonstrated that there is a high prevalence of SIgAD in T1DM patients.
We report a positive correlation between IgA Level on one hand and IgG and IgM on the other hand.
IgA level was statistically significantly lower in males than females ,and SIgAD more prevalent in females