الفهرس 
ProgesteroneOnly 14 pages are availabe for public view
Abstract
Despite the widespread use of gonadotropin-releasing hormone (GnRH) analogues for pituitary down-regulation, elevation in serum progesterone concentrations, still occurs at different frequencies on the day of human chorionic gonadotropin (hCG) administration for final oocyte maturation in fresh in vitro fertilization (IVF) cycles (Venetis et al., 2013; Huang et al., 2015).
The aim of this study is to assess the relation between serum progesterone level on the day of HCG administration and the clinical pregnancy rate as a primary outcome, quality of embryo, quality of oocyte, fertilization rate and chemical pregnancy assessed by B-HCG level 2 weeks after embryo transfer as secondary outcomes.
This prospective non interventional study was conducted at Assisted Reproduction Unit, Ain Shams University Maternity Hospital, Cairo, Egypt starting from December 2015 till March 2017.
The study included 240 women scheduled fir ICSI presented with primary or secondary infertility, the causes of infertility at this study were male factor, tubal factor and unexplained infertility.All the selected women had subjected to careful history taking with an age ranged from (18-39 years), body mass index was calculated, the mean body mass index was 29.60±7.30, hormones as basal FSH, LH, TSH, prolactin and E2 had been measured on the day 2 or 3 of the cycle, basic trans-vaginal ultrasound on day 2 or 3 of the cycle was done for antral follicle count.
Blood samples were withdrawn at the day of HCG administration for serum progesterone levels.
This study revealed that there was adverse correlation between serum progesterone at the day of HCG administration and the clinical pregnancy rate which was 34.2%, the cut of value of serum progesterone was 1.09 ng/ml above this value the cinical pregnancy rate adversely affected.
Also there is a statistically significant adverse relation between serum progesterone and the number of MII oocytes (its median was 6) which represent the quality of oocyte.
Also there was adverse relation between the serum progesterone at the day of HCG administration and the grade of embryo and fertilization rate, so premature rise of serum progesterone decreases the quality of embryo and the quality of oocytes and fertilization rate.There was a statistically insignificant difference between serum progesterone level at the day of HCG administration and the chemical pregnancy (its percentage was5.9% at this study) so the rise of serum progesterone did not affect the chemical pregnancy.
There was a statistically insignificant difference between participants with positive and negative clinical pregnancy as regards number of HMG stimulation days, number of retrieved oocytes and the dose of HMG.