الفهرس 
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Abstract
This study is designed to highlight the role of exosomal miRNAs as a novel predictor for diagnosis and to evaluate whether miR-122, miR-31 and their target genes were involved in metabolic syndrome and its related disorders.
To achieve that the following protocol was followed:
1. Preparation of high fat high sugar diet (HFHS) diet by utilization of lard and fructose that added to the standard rat chow and the caloric intake became 800 kcal per 100 g food, of which 60% provided by the lard and 17% by the fructose instead of 300 kcal for the standard rat chow to be supplied for one month after the 2 weeks of rats acclimatization. Then blood glucose was measured and rats with blood glucose more than 200mg/dl were taken as obese-diabetic group whereas that less than 200mg/dl considered as obese non-diabetic group.
2. The experiment was performed on seventy male adult albino rats that were classified into two main groups:
I. group A: Control group, rats fed on standard rat chow without treatment.
II.group B: Metabolic syndrome (MetS) group: rats fed on high fat high sugar diet for 8 weeks that subdivided into 6 groups:
group B1: MetS group (rats fed high fat high fructose diet without treatment).
group B2: MetS group supplemented models treated with Okra extract (200mg/kg) for 4 weeks.
group B3: MetS group supplemented with Gum Arabic powder (500mg/kg) for 4 weeks.
group B4: MetS group supplemented with Dapagliflozin powder (1mg/kg) for 4 weeks.