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Thermal reaction of Cr(III), Co(II), Ni(II), Cu(II), Ag(I), Sm(III) and UO22+ metal ions with the synthesized Schiff base ligand 8-((furan-2-ylmethylene)amino)naphthalene-1-amine, L, resulted in the formation of the seven complexes: [CrLCl(H2O)3]Cl2.3H2O, [CoL2(H2O)2]Cl2.3H2O, [NiL(H2O)2]Cl2.4H2O, [CuL(H2O)2]Cl2.2H2O, [AgL(H2O)2]NO3.2H2O, [SmL3](ClO4)3(H2O), and [U(O)2L2](ClO4)2. The studied compounds are characterized using different spectroscopic techniques (IR, 1H NMR, mass), elemental analyses, magnetic measurement, molar conductance, and thermal analysis. Tetrahedral structures have been proposed for Ni(II), Cu(II) and Ag(I) complexes, whereas the other complexes are found to have six coordinated octahedral geometry. The complexes have high thermal stability according to the thermal studies. The kinetic and thermodynamic parameters of the complexes are computed by Coats and Redfern method. All the synthesized compounds except Cu(II) and U(VI) can potentially serve as photoactive materials. Geometry of ligand and some complexes are optimized by Gaussian 09 software. HOMO-LUMO energy gap and quantum chemical parameters are calculated from the optimized structures by DFT method.
The X-ray diffraction pattern of ligand and its Co(II), Ni(II), Ag(I) and U(IV) complexes exhibit sharp peaks indicating their crystalline nature while Cr(II), Cu(II) and Sm(III) complexes are found amorphous in nature. Antimicrobial activities of the ligand and its complexes have been studied. Cobalt(II) and nickel(II) complexes show the highest antibacterial and antifungal activity rather than ligand and other complexes. The in vitro cytotoxicity of the ligand and its silver(I), cobalt(II) and copper(II) complexes on the breast cancer (MCF7) human cell line are determined and compared with the standard cis-platin and doxorubicin. The results show that the ligand can be considered as a moderate antitumor agent while Ag(I), cobalt(II) and copper(II) complexes could not be considered as antitumor drugs.