الفهرس 
VitiligoOnly 14 pages are availabe for public view
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Abstract
Vitiligo is a chronic disorder that causes depigmentation of the skin. It occurs when melanocytes, the cells responsible for skin pigmentation, die or are unable to function. The etiology of vitiligo is unknown. Some of the prevalent hypotheses, including the autoimmune, auto inflammatory, genetic, neural, cytotoxic, and recently, metabolic etiologies, have served as the basis for treatment formulation.
As vitiligo will often have a major effect on the quality of life, proactive treatment is frequently recommended, preferably to be started early at the active stage of the disease. Current treatment modalities are directed toward stopping the progression of the disease and achieving repigmentation.
Therapies include corticosteroids, topical immunomodulators, photo (chemo) therapy, surgery, combination therapies, and depigmentation of normally pigmented skin.
The treatment of vitiligo has not been very well targeted because we do not fully understand the etiology or the many causative factors and associations that may be involved. Therefore, there is a need for more studies to try to reveal the cause of vitiligo.
Low vitamin D levels seem to be associated with several autoimmune diseases including multiple sclerosis, systemic lupus erythematosus, undifferentiated connective tissue disease, and rheumatoid arthritis.
Vitiligo, being an autoimmune disease, could be caused or aggravated by low vitamin D levels. Approximately 25% of vitiligo patients have an associated autoimmune condition.
The present study is a case control study included 120 subjects: 60 patients with vitiligo (15 males and 45 females) and 60 apparently heathy age and gender matched controls (18 males and 42 females). The aim of the study is to find out a correlation between serum levels of vitamin D and the severity of the disease in vitiligo patients. Data is collected and analyzed and the results can be summarized as following:
There was no significant difference between cases and controls regarding age and gender.
There was a significant increase in the level of vitamin D in pateints compared to controls.
The mean level of 25(OH) D in female patients was lower than that in male patients with non significant difference.
There was non-significant negative correlation between vitamin D level and each of age and duration of vitiligo. where as nonsignificant positive correlation existed with VASI score.
There is nonsignificant statistical difference in vitamin D serum level regarding age, duration of disease, activity and family history.
The mean level of 25(OH) D in patients received NBUVB was higher than that in patients not received NBUVB with no statistical significant difference.