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Epilepsy is a neurologic condition that affects people of all ages and has no geographic, social, or racial boundaries.
Benign Rolandic Epilepsy (BRE) is the most common form of childhood epilepsy.
Ghrelin, the ”hunger hormone”, is a peptide hormone produced by ghrelinergic cells in the gastrointestinal tract, that functions as a neuropeptide in the central nervous system.
Human studies investigating the link between ghrelin and epilepsy are controversial.
Some studies assume that increased serum ghrelin may provoke seizure occurrence through prolongation of NREM sleep,
Other studies assume that increased serum ghrelin is neuroprotective and may act as an anticonvulsant through its enhancement to neuropeptide Y and GABA levels in the CNS, so may play a role in inhibition of seizure occurrence.
In this study,30 patients with epilepsy and 30 healthy controls of matched age and sex were assessed for serum ghrelin levels.
Full history taking and thorough clinical examination were done.
According to the current study, the following parameters were found:
Age of patients ranged from 4-12 years old, 67% of them were males and
33% were females.
As regard frequency of attacks, There was a significant negative correlation between ghrelin and frequency of attacks in case group.
It was also found that serum ghrelin was lower in cases than in controls,
In addition, the results showed that serum ghrelin may have a significant high diagnostic performance in differentiating case from control
As regard patients’ learning performance, it was worse in cases than in controls.
As regard patients with history of delayed language, it was found serum ghrelin was significantly lower among cases
Moreover, It was found that serum Ghrelin was non- significantly the highest in cases treated with Oxacarbazepine.
The results showed that serum ghrelin was non- significantly higher in males than in females in both groups.
So, according to this current study, it can be presumed that ghrelin is a neuroprotective agent and can be used as an anticonvulsant.