الفهرس 
PharmacologyOnly 14 pages are availabe for public view
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Abstract
Postoperative pain is an acute sensation accompanied by an inflammatory process associated with surgical trauma that decreases with tissue healing. Successful postoperative analgesia is known to prevent the majority of pain-related effects occurring in the patient.
This study was performed after obtaining approval from our institutional committee for human investigation. Informed consent was obtained from each patient. All patients (ASA physical status I and II), aged 18 to 65 were scheduled for elective laparoscopic cholecystectomy. Patients were randomly divided into 1 of 2 groups. The ibuprofen group (n=30) received 400mg IV ibuprofen in 100mL saline 30minutes before surgery, while the control group (n=30) received 100mL saline solution 30minutes before surgery. The same general anesthesia protocol was applied in both groups. Postoperative analgesia was assessed using a visual analogue pain scale (VAS) with active and passive movements.
Twenty-four hour postoperative fentanyl consumption with patient-controlled analgesia and additional analgesia requirements were recorded. Postoperative analgesia was established with 1000 mg paracetamol once every 6 hours and patient-controlled IV fentanyl and pethidine.Our study showed that twenty-four hour opioid consumption was statistically significantly higher in the control group compared to the ibuprofen group. Additional analgesia (pethidine) use was statistically significantly higher in the control group than in the ibuprofen group. This study revealed also that both VAS values and cumulative opioid consumption were significantly lower in the preemptive groups at every time point observed at postoperative 30 minutes and 1, 2, 4, 8, 12, and 24 hours than those in the corresponding control group. The rates of nausea and vomiting were higher in control group than in ibuprofen group. Other side-effects were similar between the groups. from this study we conclude that preemptive single dose of IV ibuprofen in laparoscopic cholecystectomy reduced postoperative opioid consumption in the 1st 24 hours by 45%. It generated lower pain scores in the postoperative period compared with placebo.