الفهرس 
Beta-ThalassemiasOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
This is a prospective cohort study that was conducted on forty patients with confirmed homozygous β- thalassemia major patients before and after splenectomy.
All cases were subjected to complete physical examination by assessing anthropometric measurements, vital signs, presence of pallor, jaundice, spleen and liver status. Routine laboratory investigations, complete blood picture with blood indices in addition to reticulocytic count, liver enzymes and ferritin level, measuring plasma malondialdehyde and total antioxidant, catalase enzyme, glutathione s-transferase, IL-6 ,IGM and complement 3 .
Our results showed that regarding blood characteristics there is higher mean hemoglobin after splenectomy was 7.9 g/dl compared to pre splenectomy level 7.5 g/dl and the difference is statistically highly significant with higher mean platelets after surgery 427.6 compared to 203.5 before surgery with 110% rise in the mean platelet count and the difference is statistically highly significant and There is a higher mean increases in the mean WBCs 12.4 compared to 8.7 before surgery and the difference is statistically highly significant with 42.5% increase, there is a lower mean reticulocytic count after splenctomy compared to pre surgery level with a DROP of 41% in the mean level of reticulocytes and the difference is statistically highly significant.
After splenectomy we found in our study a significant higher increase in the mean ferritin and the difference is statistically highly significant, there is a rise in the mean AST after splenectomy compared to pre surgery level and the difference is statistically highly significant. (Increase in the mean level by 18%) and there is a rise in the mean ALT after splenectomy compared to pre surgery level and the difference is statistically highly significant. (Increase in the mean level by 22%).
In our study showed that regarding immune status we found that there is a decrease in the mean Interleukin 6 after splenectomy compared to pre surgery level and the difference is statistically highly significant. (Decrease in mean level of IL6 by 36%) with decrease in the mean level of IGM after splenectomy compared to pre surgery level and the difference is statistically highly significant. (Decrease in mean level of IGM by 12.6%) and there is a slight increase in the mean level of C3 after splenectomy compared to pre surgery level and the difference is not significant statistically.
In our study showed that regarding antioxidant status we observed a decrease in the mean MDA after splenectomy compared to pre surgery level and the difference is statistically highly significant. (Decrease in mean level of MDA by 39%), there is an increase in the mean level of Total antioxidant capacity after splenectomy 0.96 compared to 0.57 before surgery and the difference is statistically highly significant. (68% increase in the mean level of Total antioxidant capacity), the enzymatic antioxidant CAT was significantly increased after splenectomy 0.69 compared to 0.40 before surgery and the difference is statistically highly significant. (72.5% increase in the mean level of Catalase) and we found that there is a slight decrease in the mean gulathione transferase after splenectomy compared to pre surgery level and the difference is not significant statistically. (Decrease in mean level of glutathione transferase by 4%).