Search In this Thesis
   Search In this Thesis  
العنوان
Role of MRI in Assessment of Nodular Focal Lesions in Cirrhotic Liver \
المؤلف
Abdulameer, Ahmed Riyadh.
هيئة الاعداد
باحث / أحمد رياض عبد الأمير الحيدري
مشرف / سامـــر مـــلاك بطــرس
مشرف / منة الله حاتم شلبي
مناقش / سامـــر مـــلاك بطــرس
تاريخ النشر
2017.
عدد الصفحات
141 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الأشعة والطب النووي والتصوير
تاريخ الإجازة
1/1/2017
مكان الإجازة
جامعة عين شمس - كلية الطب - الآشعة التشخيصية
الفهرس
Only 14 pages are availabe for public view

from 141

from 141

Abstract

Cirrhotic livers are characterized by advanced fibrosis and formation of hepatocellular nodules which are classified histologically as either regenerative nodules, dysplastic nodules, or neoplastic lesions. However, their accurate characterization may be difficult even at histopathological analysis. Differential diagnosis may be facilitated by comparing the clinical and pathological findings with radiological imaging features.
MR imaging is more useful than CT and US in diagnosing the premalignant cirrhotic nodules from the malignant ones as it is the main issue for early detection and management of HCC. MRI provides better soft-tissue contrast and identification of different tissue properties by their signal appearance on different MR phases while in MSCT we judge only on dynamic post contrast study. Moreover, a wide variety of contrast agents are currently available for use in MR imaging.
For hepatic focal lesions detection and characterization, conventional MRI relies on T1-weighted, T2-weighted and dynamic gadolinium-enhanced T1-weighted imaging.
This study was designed to assess the role of MRI using intravenous Gd- DTPA as a contrast medium in evaluation of nodular hepatocellular nodules in cirrhotic livers on unenhanced and contrast-enhanced MR images.
Forty patients with 90 cirrhotic liver nodules were examined by MRI and the results were compared to those histopathological assessment in most of the patients. The detected nodules were classified into; group (A) 63 (70%) HCC lesions, group (B) 1 (1.1%) dysplastic nodule, group (C) 20 (22.2%) regeneration nodules, group (D) 6 (6.7%%) metastatic lesions.
This MR study enabled us to visualize the cirrhotic liver nodules based on; their signal intensity pattern on different MR phases, good tissue characterization for intracellular fat & iron content inside the nodules by the dual in-phase and out-phase images, and their enhancement pattern in dynamic post contrast study. It also enabled us to detect any vascular invasion in malignant neoplastic hepatic lesions for proper staging assessment.