الفهرس | Only 14 pages are availabe for public view |
Abstract T he purpose of the current study is to compare the clinical features, histopathologic characteristics and survival outcomes in young patients with those in the older age group in Egyptian patients, and to assess the role of p53 expression in prognosis with histopathological characteristics and other clinical variants of CRC tumor. The present study deals with 137 cases of CRC taken from histopathological reports. They were 53 cases ≤ 40 years old (38.7%), and 84 cases > 40 years old (61.3%), ages ranged from 23 years to 78 years with mean age 47.3 ± 14.4 years. they were 55 males (40.1%), and 82 females (59.9%) (M: F = 0.6:1). Out of the 137 cases, 56 cases that had histological slides and blocks were examined histologically to confirm malignancy, and their characteristics. These cases were stained with p53 later on, they were 32 cases positive p53 expression (57.1%) and 24 cases negative p53 expression (42.9%). they were 24 cases ≤ 40 years (42.9%) and 32 cases > 40 years (57.1%), their age ranged from 24 years to 76 years with mean age 47.3 ± 13.7 years. The results of the present study is divided into two main categories: The first one, statistical correlations between age with other variables, in which there were statistically significant relations between age and tumor size, tumor type and tumor location. On the other hand, there were no significant relations between age and tumor grade, tumor stage, N stage, overall survival and outcome. The second main category is statistical p53 expression in correlations with other variables, in which there were significant relations between female gender, tumor type (adenocarcinoma) and positive p53 expression. Conversely, we didn’t find significant statistical correlation between p53 expression and tumor size, tumor site, tumor grade, tumor stage, N stage and with other tumor behavior characteristics as lymphovascular invasion, perineural invasion and lymphocytic infiltration. Finally, regarding to overall survival and fate also we couldn’t find any correlation with p53 expression. In conclusion, CRC in young patients seems to be different from that in old patients in the pathologic characteristics of the tumor as tumor location, size and histologic type rather than patient outcome and survival. However, this needs to be further investigated on a larger number of patients. |