الفهرس 
Pregabalin BackgroundOnly 14 pages are availabe for public view
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Abstract
The administration of oral pregabalin preoperatively has been reported to reduce acute postoperative pain. However, no clinical study to date has yet fully investigated whether or not pregabalin premedication affects sensory and motor blocks using spinal anesthesia and its effect upon early postoperative pain management. This prospective, randomized, and double-blind clinical study was designed to evaluate the efficacy of a single dose of pregabalin in terms of spinal blockade duration and its potential opioid-sparing effect during the first 24 hours post operatively
The aim of this work is to evaluate the efficacy of a single dose of pregabalin in terms of spinal blockade duration and its potential opioid-sparing effect during the first 24 hours postoperatively.
The patients will be randomly divided into two groups using their medical record number (MRN) such that even numbers will be enrolled in group The patients will be randomly divided into two groups:
Groupe A that will receive pregabalin 150 mg orally one hour preoperatively
Groupe B will not receive it.
Data collected are vital data, NPRS score, when the need for analgesia post operatively for 24 hours.
In this study, a single dose of 150 mg pregabalin 2 hours before spinal anesthesia showed sufficient efficacy during the first postoperative 24 hours. Pregabalin has an elimination half-time estimated to range from 5.5 to 6.7 hours, which is independent of the dose and frequency of administration