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العنوان
Leukocytes as a Potential
Biomarker for Osteoarthritis /
المؤلف
Elkhodary,Hesham Mohamed Asaad.
هيئة الاعداد
باحث / Hesham Mohamed Asaad Elkhodary
مشرف / Ahmed Sami Kamel
مشرف / Ahmed Mohamed Mohasseb
تاريخ النشر
2019
عدد الصفحات
120p.:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
جراحة العظام والطب الرياضي
تاريخ الإجازة
1/1/2018
مكان الإجازة
جامعة عين شمس - كلية الطب - جراحة العظام
الفهرس
Only 14 pages are availabe for public view

from 120

from 120

Abstract

Osteoarthritis is the most common type of adult joint
disease, and is increasing in frequency and severity.
Although osteoarthritis is commonly described as noninflammatory
joint disease, synovial inflammation is
increasingly recognized as contributing to the symptoms and
progression of osteoarthritis. Osteoarthritis pathophysiology is
complex. However, these inflammatory processes were
interpreted mainly as a bystander, and not as a driving force in
osteoarthritis pathogenesis. A set of new studies has raised
interest in this topic and aimed to map these inflammatory
processes more precisely. Studies have shown that patients with
inflammation show faster osteoarthritis progression, confirming
the hypothesis that inflammation has an impact on disease
progression A major problem in cartilage repair is the lack of
chondrogenic cells migrating from healthy tissue into defects
and being essentially avascular. Microscopic examination in
early osteoarthritis revealed for more than half of patients with
synovial biopsy through arthroscopic technique having
synovitis lesions with mononuclear infiltrates, diffuse fibrosis,
thickening of the lining layer, macrophages appearance and
vessels neoformation as well.
Aiming to figure out the role of leukocytes in prediction,
diagnoses and prognosis of osteoarthritis. Finding whether
leukocytes may serve as biomarkers for both early diagnosis and, perhaps more importantly, identification of osteoarthritis
patients at higher risk for disease progression.
Two hundred knees of patients with symptoms and signs
suggestive of Osteoarthritis were collected from outpatient
clinic of Orthopaedics Department, Ain Shams University
Hospitals. In clinic practice, plain radiographs are a readily
available and cost-effective means of assessing the knee joint.
In combination with the patient’s symptoms and physical exam,
radiographs are used to grade the severity of knee OA along
with the KOOS questionnaire. Inclusion criteria:
1. Radiological findings: narrowing of joint space, subchondral
sclerosis and bony osteophyts. 2. Joint swelling on inspection,
crepitus and tenderness on palpation. Exclusion criteria:
1- History of any previous injections of the Knee. 2- Previous
knee injury or surgery. 3- Rheumatoid arthritis 4-Cancer
especially hematopoietic or of bone. The study was conducted
on 200 patients diagnosed with primary osteoarthritis. All
patients will be subjected to the following: Full medical history
taking and thorough clinical examination, stressing on joints
examination. Plain x-rays for both knees, synovial fluid tapping
for detection of leucocytes, and KOOS questionnaire filling.
Result shows that there was highly statistically
significant increase in synovial fluid white cell count with the
increase of severity. There was statistically significant relation
found between severity of osteoarthritis and age while no
statistically significant relation found with sex or BMI. Side of knee examined and appearance of synovial fluid aspiration
samples did not show significant relation with severity of
osteoarthritis. There was highly statistically significant inverse
relation found between severity of osteoarthritis and KOOS
score.