الفهرس 
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Abstract
The present study aimed to examine effect of extraction methods on the antioxidant activities and total phenolics of carob pulp powder (CPP).Moreover, the study extended to evaluate the influence of carob pulp powder on liver and kidney functions as well as serum lipid profile of rats treated with carbon tetrachloride(CCl4). Carob pulp powder extracts showed considerable differences in antioxidant activity (AA=83.18-96.06%). Methanolic extract (MeOH) showed a strong activity ,while aqueous extract showed relatively low antioxidant activity. Total phenolic content of the different CPP extracts varied from 2360 to 4348 mg/100 g dry product. there was a positive and highly significant (p≤0.001)relationship between total phenolics and antioxidant activity (R2=0.9248).Obtained data showed that rats fed diets contained different levels of carob pulp powder (2.5, 5, 7.5, 10%) for 28 days (as protective groups) had significant changes in body weight gain and feed efficiency ratio as compared to rats fed basal diet and injected with carbon tetrachloride (G2).However, feed intake (F1) did not significantly change among all tested rats groups. Also, it was noted that induction rats with CCl4 caused elevation in levels of AST, ALT, ALP, creatinine, glucose, triglycerides,total cholesterol, low density lipoprotein cholesterol (LDL-c) ,very low density lipoprotein (VLDL-c) and malondialdehyde (MDA). In the same time, high density lipoprotein cholesterol (HDL-c), superoxide dismutase(SOD), catalase (CAT) enzyme activity and glutathione (GSH) levels were reduced. On the other hand, feeding rats diets supplemented with different levels of carob pods powder (2.5, 5, 7.5 and 10%) improved all parameters,especially when the higher levels were used. It was concluded that carob powder improved functions of liver and kidney, glucose levels, lipid profile and biological antioxidants of rats induced with CCl4. The histopathological examination of liver confirmed this improvement.