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العنوان
Expression of micro RNA-9 in Patients
with Acute Myeloid Leukemia and its
Impact on Treatment Strategy /
المؤلف
Youssef, Mysra Sami.
هيئة الاعداد
باحث / Mysra Sami Youssef
مشرف / Mona Ahmed Ismail
مشرف / Hanaa Rasmy Mohamed Attia
مناقش / Mona Hamed Ibrahim Farag
تاريخ النشر
2018.
عدد الصفحات
136 P . :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض الدم
تاريخ الإجازة
1/1/2018
مكان الإجازة
جامعة عين شمس - كلية الطب - قسم امراض الدم
الفهرس
Only 14 pages are availabe for public view

from 136

from 136

Abstract

AML is a malignant disorder of hematopoietic tissue. It is one of the most common malignancies in adults. It is characterized by its heterogeneous and complex nature that includes chromosomal, genetic and epigenetic abnormalities. MicroRNAs have been described to be one of the epigenetic regulators in AML.
The present study focused on measuring expression levels of miR-9 in de novo AML patients.30 bone marrow samples were collected from patients attending at hematology and oncology unit of Aldemerdash hospitals. MiR-9 expression levels were measured using real time PCR. These expression levels were compared to 30 adult healthy volunteers.
Statistical analysis of the results showed that miR-9 was significantly down regulated in AML patients in comparison to controls. It is also significantly correlated to platelet count. Regarding diagnostic performance, this study showed that miR-9 has weak diagnostic performance but regarding screening function, it has high sensitivity but moderate specificity so it can be used as an excluding test.
In conclusion, this study showed reduction of miR-9 in bone marrow of AML patients and opened the horizon for future studies on diagnostic and screening performance of miR-9 to be performed on larger scale and different ethnic groups.