الفهرس | Only 14 pages are availabe for public view |
Abstract AML is a malignant disorder of hematopoietic tissue. It is one of the most common malignancies in adults. It is characterized by its heterogeneous and complex nature that includes chromosomal, genetic and epigenetic abnormalities. MicroRNAs have been described to be one of the epigenetic regulators in AML. The present study focused on measuring expression levels of miR-9 in de novo AML patients.30 bone marrow samples were collected from patients attending at hematology and oncology unit of Aldemerdash hospitals. MiR-9 expression levels were measured using real time PCR. These expression levels were compared to 30 adult healthy volunteers. Statistical analysis of the results showed that miR-9 was significantly down regulated in AML patients in comparison to controls. It is also significantly correlated to platelet count. Regarding diagnostic performance, this study showed that miR-9 has weak diagnostic performance but regarding screening function, it has high sensitivity but moderate specificity so it can be used as an excluding test. In conclusion, this study showed reduction of miR-9 in bone marrow of AML patients and opened the horizon for future studies on diagnostic and screening performance of miR-9 to be performed on larger scale and different ethnic groups. |