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العنوان
Effect of Vitamin D Supplementation on Elders Muscle Function \
المؤلف
Mohamed, Tomader Taha Abdel Rahman.
هيئة الاعداد
مشرف / تماضر طه عبد الرحمن محمد
مشرف / محمد شوقى خاطر
مشرف / محمد فاروق علام
مناقش / محمد شوقى خاطر
تاريخ النشر
2019.
عدد الصفحات
95 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الشيخوخة وعلم الشيخوخة
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية الطب - التغذية الإكلينيكيه
الفهرس
Only 14 pages are availabe for public view

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from 95

Abstract

In spite of many researchers decided to investigate the effects of vitamin D supplementation on muscle function but the results remains controversial and it remains difficult to conclude whether vitamin D supplementation has an effect on muscle strength for the elders (Avenell et al., 2014).
Published RCTs on sarcopenia and vitamin D supplementation were identified through a comprehensive Pub-Med and Med-Line search (from January 2000 to June 2018) using a variety of keywords and subject headings related to sarcopenia, vitamin D supplementation, muscle strength and elderly. We conducted additional searches of Egyptian Knowledge Bank, previously published reviews, examination of cited reference sources, and personal contact and discussion with several investigators expert in the field. Published descriptive and analytical observational studies dealing with sarcopenia and vitamin D were excluded. We did not attempt to locate any unpublished studies.
Only RCTs with older persons >60 years of community-dwelling elderly were included. We applied no restrictions for dose, forms and duration of vitamin D supplementation, and follow-up duration, with or without calcium supplements or dietary advice. Measures of muscle function included muscle strength by Hand grip strength (HGS), and physical performance by Timed-up-and-go test (TUG). These measures were compared before and after intervention for both groups (vitamin D supplementation versus placebo).
We included a sum of 14 RCTs, with a total of 2127 participants aged 60 years and older. The average ages of the included participants were 68.8 years (ranges from 60 to 88 years). The ratio of women to men was approximately 3.25: 1 (1627/500).
All selected studies determine that they had a randomization in their design. The participants were all community-dwelling older individuals, who were generally in age-related good health. All studies excluded patients with acute illnesses.
Vitamin D was measured as 25(OH)D concentration in all included RCTs, using chromatographic methods, radioimmunoassay (DiaSorin Inc., Stillwater, MN, USA), IDS Gamma-B 25-OH immunoassay (IDS, Tyne & Wear, UK), Liaison method (DiaSorin Inc.). One RCT study did not report which method had been used. The mean baseline concentration of vitamin D was ranging from 11 to 55 nmol/L.
One RCT used different dosage for supplementations, and another RCT used different duration of follow up and we considered every one as two clinical trials.
Vitamin D3 supplementation was used orally with various doses (range from 400 – 3333 IU), and treatment periods (ranges from 3 months – 24 months).
Seven of the fourteen included RCTs added calcium supplements to vitamin D supplement. The dose of calcium supplementation ranges from 500 to 1000 mg. Two studies evaluated the overall nutrient intake beside supplementation.
The pooled mean difference of hand grip strength in vitamin D supplementation groups was higher than that of control groups. Timed-up-and-go test pooled mean difference was slightly lower in vitamin D supplementation groups compared with control groups. Our meta-analysis shows that vitamin D supplementation could improve the muscle function in elder people.