الفهرس 
Chronic Kidney Disease (CKD)
Cerebrovascular diseaseOnly 14 pages are availabe for public view
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Abstract
CKD is a worldwide health problem because of the significant rate of morbidity and mortality. The most important cause of mortality in CKD is atherosclerosis which is mostly due to inflammation that develops in early stages of CKD. Proteinuria is the basic indicator of renal damage. It has an important role of development of fibrogenesis and glomerulosclerosis associated with the progression of several renal diseases. MPV and NLR are indicators of inflammation in many disorders. They are very valuable, cost effective and easy markers as they can be evaluated by a simple blood count. The present study was aimed to study the relation between MPV and NLR in CKD patients with proteinuria The present study was conducted on 100 subjects: The subjects of this study were classified into two groups: group I: 50 CKD patients from out patients nephrology clinic in Internal medicine department at Tanta University Hospital group II: 50 healthy persons as a control group. Subgroups of CKD patients: - group (1): includes 7 patients with renal impairment stage 1 CKD. - group (2): includes 8 patients with renal impairment stage 2 CKD. - group (3): includes 12 patients with renal impairment stage 3 CKD. - group (4): includes 13 patients with renal impairment stage 4 CKD. - group (5): includes 10 patients with renal impairment stage 5 CKD. - 110 - Exclusion criteria: 1. Patients suffer coronary artery disease, myocardial infarction and heart failure. 2. Patients suffer from active infection. 3. Patients suffer from diabetes mellitus. 4. Patients suffer from malignancy. All patients and controls included in the study were subjected to the following: 1-Full history taking: Including age, sex and history of any other associated diseases and therapeutic therapy. 2-Complete clinical examination: All patients and controls were subjected to complete physical examination with special stress on: General examination: Pulse, blood pressure (measured with sphygmomanometer while subjects were sitting after resting for 5 minutes), edema of lower limb, soft tissue infection and body mass index (BMI) calculation. Chest and heart examination. Abdominal examination For kidneys, liver, spleen and free peritoneal fluid. 3-Laboratory investigations: A) Routine Laboratory investigations: Complete blood count (CBC). Lipid profile (Triglyceride, Cholesterol, LDL and HDL). Serum uric acid. Kidney functions (urea and creatinine). Urine analysis. Fibrinogen. 24 hours urine protein collection. Glomerular filtration rate (GFR). C-reactive protein (CRP). B) Specific investigations: Neutrophil –lymphocyte ratio (NLR). Mean platelet volume (MPV) 4-Imaging including: Abdomen sonography The main finding can be summarized as follows: NLR was significant higher in CKD patients group than healthy control group and it was positively correlated with the progression of CKD stages. NLR was positively correlated with proteinuria. NLR was positively correlated with CRP and fibrinogen. MPV was lower in CKD patients group than healthy control individuals but it was not statically significant. MPV was not correlated with proteinuria. MPV was not correlated with CRP and fibrinogen.