الفهرس 
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Abstract
Background: Urolithiasis is one of the most common urological diseases. Medical expulsive therapy includes α-adrenergic blockers , anti-inflammatory drugs , and calcium channel blockers, which have a relaxant effect on the ureteric smooth musculature. This study investigate whether a PDE5 inhibitor could be used for Medical expulsive therapy for distal ureteral stones 5-10 mm or not.
Purpose: To compare between the effect of Sildenafil Citrate 50 mg once daily and tamsulosin 0.4 mg once daily on spontaneous passage of distal ureteral stones (DUS).
Patients and Methods: the study included 100 patients who have visited the urology outpatient clinic of Ain-Shams university hospitals and Helwan university hospitals, over a duration of 11 months. The 100 patients were divided into two groups, one that subjected to Tamsulosin 0.4 mg once daily (group A) and the other that subjected to Sildenafil Citrate 50 mg once daily (group B).
Results: In all, 48 and 49 patients were available for analysis in both the tamsulosin and sildenafil citrate groups; respectively. Both groups were comparable for age and stone characteristics. Spontaneous expulsion occurred in 34 of 48 patients (70.8%) in the tamsulosin group and in 31 of 49 (63.3%) in the sildenafil citrate group. The mean time to stone expulsion was shorter in the tamsulosin group but it was statistically insignificant.
Conclusion: Sildenafil is effective as a MET for 5-10 mm DUS as it showed a comparable results to Tamsulosin.