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Very recently, the World Obesity Federation argued that ‘obesity was considered as a chronic, relapsing, progressive, disease process’ that requires intervention (Bray et al.,2017).
Obesity is a complex chronic disorder with a multifactorial etiology involving genetics, hormones, diets, and environments (Kollias and Sfikakis., 2010).
Neurotensin is expressed in the brain as well as it is localized in specialized enteroendocrine cells of the small intestine (Ratner et al., 2016).
Recent work reporting that Neurotensin deficient mice are protected against diet-induced obesity. The findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment (LI et al., 2016).
The aim of the work was to evaluate the serum level of neurotensin in various grades of obesity and it’s relation to fatty diet.
We conducted our study on 60 obese patients in addition to 25 normal weight persons who are serving as a control group.
Patients were subdivided into four groups according to their degree of obesity as follow : fifteen overweight patients, fifteen obese class I patients, fifteen obese class II patients and fifteen obese class III patients.
Patients were compared to a Control group comprising twenty five apparently healthy non obese individuals of matched age and sex.
All patients were subjected to full medical history taking, bowel habits history, detailed dietary habits (detailed fat-intake questionnaire), thorough clinical examination and clinical assessment according to BMI. Also serum neurotensin , random blood sugar, thyroid profile and lipid profile were measured.
Our study revealed significant higher level of serum neurotensin in the study group than the control group.
Our study revealed significant positive correlation between serum neurotensin, high cholesterol, low HDL and total fat intake questionnaire. But no correlation was found between serum neurotensin and TGs, LDL and the level of fat intake according to fat intake questionnaire.
Our study revealed that there is no correlation was found between serum neurotensin and age or sex.
Our limited data suggest that serum neurotensin may play a potentially important role in the development of obesity in people with high BMI consuming fatty diet.