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العنوان
Retrospective Study of characteristics of Hepatocellular Carcinoma of Cases in Ain Shams University Hospital, Internal Medicine Department :
المؤلف
Mahmoud, Doaa Abd Elaziz.
هيئة الاعداد
باحث / دعاء عبد العزيز محمود
مشرف / خالد حسن محمد حميدة
مشرف / شريف منير محمد
مشرف / زينب أحمد علي الدين
تاريخ النشر
2015.
عدد الصفحات
161 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة عين شمس - كلية الطب - الباطنة العامة
الفهرس
Only 14 pages are availabe for public view

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Abstract

Hepatocellular carcinoma (HCC) is one of the most common and important cancers in the world, and is associated with poor prognosis. It is considered as one of the most challenging tumors with high incidence, prevalence and mortality rates. It is the sixth most common cancer worldwide, accounting for 7% of all cancers and an estimated incidence that is almost identical to the mortality rate. Moreover, it represents the third cause of cancer related deaths. The incidence of HCC varies widely according to geographic location. Sub-Saharan Africa and eastern Asia are two high-incidence regions.
The treatment of hepatocellular carcinoma (HCC) is rapidly evolving as loco-regional and systemic therapies continue to improve. Image-guided radiofrequency (RF) ablation is established as the treatment of choice for patients with early-stage HCC when transplantation or resection are precluded.
Transarterial chemo-embolisation (TACE) is the standard of care for patients with multinodular disease at the intermediate stage.
This study was held in internal medicine department, Ain Shams University Hospital to set up a data base on cases of HCC from January 2011 to December 2011, All files of patients presented by hepatic focal lesion in internal medicine department or the hepatology outpatient clinic during this period from was included in the study.
All the files was revised for history, physical examination, laboratory investigations with special stress on liver function tests, complete blood count, kidney function tests and tumour markers (AFP), radiological investigations including: abdominal ultrasound and triphasic abdominal CT(with stress on characteristic of the focal lesions), and treatment modalities including: surgery, radiofrequency, chemoembolization and conservative treatment.
The data was collected and statistically analyzed.
It was found that:
The mean age was 55.5±9.1. 76.8% of studied cases were males while 23.2% were females. As for child classification most of our patients were child B (%) 63.4% of cases had single focal lesion, 25.3% had 2-3 focal lesions while 11.3% had >3 focal lesions. 3.5% of lesions were sized < 2 cms, 26.8% were sized 2-5 cms while 69.7% were sized >5 cms. In 68.3% of cases the focal lesion was sited in the right lobe, in 22.5% it was sited in the left lobe while in 9.2% it was sited in both lobes.
Concerning the tumor characteristics, single lesion (63.4%), right lobe predominance (68.3%) and larger size than 5 cm were the predominant features.
As regard intervention done for the cases, chemoembolization only was done in 21.8% of cases, R.F only was done in 10.6% of cases, chemoembolization and R.F was done in 3.5% of cases, microwave ablation was done in 0.7% of cases, surgical excision was done in 1.4% of cases while 62% of cases were beyond intervention with just supportive care.
There was no significant difference between number of focal lesions as regards to age, sex, Child classification and laboratory findings.
Also, there was no significant difference between lesion sizes as regards to age, sex and Child classification
AFP was non-significantly higher in cases with >5cm focus size than 2-5 cm focus size.