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العنوان
Salivary CXCL-13, ultrasonography and scintigraphy in early detection of secondary Sjogren’s syndrome /
المؤلف
Moussa,Salwa Galal.
هيئة الاعداد
باحث / Salwa Galal Moussa
مشرف / Hanan El-Sebaie El-Hefnawy
مشرف / Heba Fawzy El-Shishtawy
مشرف / Dalia Mohamed Ezz El-Din
تاريخ النشر
2018.
عدد الصفحات
238p.;
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الطب البديل والتكميلي
تاريخ الإجازة
1/1/2018
مكان الإجازة
جامعة عين شمس - كلية الطب - الطب الطبيعي والروماتيزم والتأهيل
الفهرس
Only 14 pages are availabe for public view

from 238

from 238

Abstract

Background: Sjogren‘s syndrome (SS) is a systemic autoimmune disease in which immune cells attack and destroy the exocrine glands. CXCL13 directs B-cell chemotaxis and is elevated in several autoimmune diseases.
Objectives: To assess the role of salivary CXCL13 level as a screening tool in early detection of secondary Sjogren‘s syndrome (sSS) patients.
Patients and methods: Salivary CXCL13 levels using ELISA technique, Schirmer paper test and/or Lissamine green (LG) staining, quantitative salivary scintigraphy excretion fraction (EF) were measured in 45 selected patients with primitive connective tissue disease (rheumatoid arthritis RA, systemic lupus erythematosus SLE, or systemic sclerosis SC) and according to American-European Consensus group (AECG) criteria (Vitali et al., 2002), they were classified to 3 equal groups, group I were having SS, group II were having dryness manifestations but not completing the criteria for SS diagnosis (suspected SS), group III were having no SS. And 15 age and sex matched apparently healthy controls.
Results: A significantly higher salivary CXCL13 level on comparing SS patients to suspected, non SS groups and controls (P < 0.001). Salivary CXCL13 had a significant negative correlation with scintigraphy (P < 0.01), a significant positive correlation with eye dryness signs ( P < 0.01), cut-off value of CXCL13 to diagnose SS was >40 pg/ml and cut-off value of salivary scintigraphy EF to diagnose SS was <33.1%. Conclusion: Salivary CXCL13 is a sensitive biomarker in early detection of secondary SS (sSS).
Key Words: Sjogren‘s syndrome, salivary, CXCL13, scintigraphy.