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العنوان
Vitamin D And Its Relation to Lupus Nephritis /
المؤلف
Sarbeet, Amer Shawi.
هيئة الاعداد
باحث / عامــر شــاوي سـربيت
مشرف / عادل محمود على السيد
مشرف / سماح عبد الرحمن البكرى
مشرف / نوران أسامة أحمد العزيزي
تاريخ النشر
2015.
عدد الصفحات
221 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الروماتيزم
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة عين شمس - كلية الطب - الباطنة العامة والروماتيزم والمناعة
الفهرس
Only 14 pages are availabe for public view

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Abstract

Vitamin D is a steroid hormone with pleiotropic effects, the association between vitamin D level and lupus nephritis are not clearly known.
Our aim is the assessment of vitamin D level in SLE patients and its relation to lupus nephritis and SLE activity.
Our study was conducted on 60 female patients with systemic lupus erythematosus .These patients were recruited from the outpatients and inpatients of Ain Shams Hospital Rheumatology clinic and Rheumatology department respectively and they subdivided into 30 SLE patients with nephritis and 30 SLE patients without nephritis. 20 age and sex matched healthy individuals were included, serving as a control group . All SLE patients fulfilled the revised American Rheumatism Association criteria for systemic lupus erythematosus (Hochberg, 1997).
These patients were subjected to full clinical examination and laboratory investigations including (CBC, ESR, CRP titer, BUN, S. creatinine, P/C ratio, ANA titer, dsDNA, C3, C4, urine analysis), and vit.D estimated by ELISA.
Disease activity assessment for the patients were done by using SLEDAI score.
We found that the mean level of vitamin D in SLE patients with nephritis was 14.9 ± 11.6 ng/ml, in SLE patients without nephritis was 31.4 ±21.3 ng/ml and in control group was 54.7± 23.9 ng/ml.
The difference was highly statistically significant, where vitamin D level was lower in patients with nephritis compared to patients without nephritis and those in control group.
As regard SLEDAI score, we found a highly statistically significant difference between SLE patients with nephritis and those without nephritis. where the SLEDAI score is higher in patients with nephritis compared to patients without nephritis (negative correlation between vitamin D level and SLEDAI score).
We classified our patients according to the vitamin D level into 3 groups; group of deficient vitamin D level(< 10 ng/ml), group of insufficient vitamin D level (10- 30 ng/ml) , group of normal vitamin D level (30-100 ng/ml). In SLE patients with nephritis there was 46.67% had deficient vitamin D level , in patients without nephritis 6.67% had deficient vitamin D level and in control group there was no vitamin D deficiency.
We found highly statistically significant difference between groups as regard laboratory investigations as WBC, Hb% and platelet count were lower in SLE patients with nephritis than those SLE patients without nephritis than those in control group, while ESR, P/C ratio, BUN, and S.creatinin were higher in patients with nephritis than those SLE patients without nephritis than control group. Also we found that there is a statistically positive correlation between vit.D level and (W.B.C, Hb%, Platelet count, C3 and C4) and negative correlation between vit. D and (ESR,S. Creatinine, BUN, P/C ratio and SLDAI score).