الفهرس 
Down’s SyndromeOnly 14 pages are availabe for public view
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Abstract
Down syndrome is a genetic syndrome most commonly caused by a third copy of chromosome 21 (trisomy 21), although a small number of cases are due to mosaicism and translocation of material from chromosome 21.
Children with Down syndrome often have reduced speech intelligibility, which is likely due to multiple factors, including: craniofacial dysmorphology, speech motor impairment (hypotonia along with articulatory placement and sequencing disorders), hearing loss, and cognitive limitations (Wild et al., 2015).
The data presented in this study established to analyze the speech of children with Down’s syndrome in order to detect types and significance of speech disorders affecting speech intelligibility; this will help in putting the best strategy for therapy.
The study was carried out between March 2017 and June 2018, on 30 child with Down syndrome aging up to 14 years, The children were randomly selected from the unit of Phoniatrics at Ain-Shams University, with variable socioeconomically standard in order to be representative as much as possible.
The inclusion criteria for children was that they should be Native Arabic speakers with history of speech and language delays, Their mean sentence length varying from 3 to 5 word sentence to enable easy taking of the speech sample required for assessment.
Each child was subjected to a detailed schedule of data collection including history taking, general examination, Auditory perceptual assessment (APA) of speech, Articulation test the Arabic Ain Shams Articulation test (Kotby et al., 1986), speech intelligibility test, Stuttering Severity Instrument for Children and Adults-Arabic version (ASSI) (Rifaie, 1999), mental status examination by Standford Binet Intelligence Scale (Terman and Merril, 1961), Nasometer (Kay model 6200-2), Speech intelligibility test (Abdel Hamid et al., 2010) and language testing by modified PLS-4 test Arabic edition (Abo Hassiba, 2011).
The data was presented and suitable analysis was done according to the type of data obtained for each parameter.
i. Descriptive statistics.
ii. Analytical statistics.
• There was a direct correlation between speech intelligibility test and mental age.
• The mean speech intelligibility test of the studied group was 49.77% ±13.41.
• The mean nasal sentence and oral sentence of the studied group was 48.47 and 12.92, respectively.
• There was a correlation between speech intelligibility test and nasal sentence.
• There was no statistically significant difference between speech intelligibility test and ASSI degree.
• There was a correlation between speech intelligibility test and frequency of articulatory errors whatever the type of these errors.
These data may be used as guidelines to detect significance of speech disorders affecting speech intelligibility; this will help in putting the best strategy for therapy.