الفهرس | Only 14 pages are availabe for public view |
Abstract • Type 1 diabetes mellitus (T1DM) is an inflammatory disease of the pancreatic islets that results in absolute insulin deficiency and the consecutive hyperglycemia due to immune-mediated beta cell destruction. • Although β cell death is the pathophysiological core of T1DM, recent data suggest that the disease associated metabolic disturbances represent a common feature of autoimmunity and insulin resistance (IR) caused by adipocyte derived pro-inflammatory factors, chronic activation of innate immune system, and low-grade inflammation. • Out of recently identified adipocytokines, dipeptidyl peptidase-4 (DPP-4) and tumor necrosis factor alpha are important in the pathogenesis of IR in type 1 Diabetes. • Our study aimed to focus on the relationship between Serum DPP-4 enzyme, TNFα and Insulin sensitivity measured by eGDR in type 1 diabetes mellitus patients. • Our results found out that the group with lower insulin sensitivity (eGDR ≤ 6.125), had higher levels of DPP-4, WHR, HbA1c, TNFα, in comparison to the second group (eGDR ≥6.125). • Males in our study had lower Insulin sensitivity than females, but higher TNFα, DPP-4, HbA1c than females • This study proved that Insulin sensitivity was negatively related to DPP-4. • TNF α, HbA1c, WHR • We found out that TNF α was positively significantly related to DPP-4, HbA1c, WHR, but had a negative significant relationship with Insulin sensitivity. • Our study proved that serum level of DPP-4 had a highly significant positive relationship with WHR, TNFα, HbA1c and negative relationship with eGDR. |