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العنوان
Studying the relationship between Dipeptidyl peptidase-4 enzyme level, Tumor necrosis factor alpha enzyme level, and insulin resistance in type 1 Diabetes Mellitus patients /
المؤلف
Abdel Salam, Mahmoud Nabil Abdou.
هيئة الاعداد
باحث / محمود نبيل عبده عبد السلام
مشرف / حنان محمد عامر
مشرف / مرام محمد ماهر مهدي
مشرف / وسام السيد سعد
تاريخ النشر
2018.
عدد الصفحات
146 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الغدد الصماء والسكري والأيض
تاريخ الإجازة
1/1/2018
مكان الإجازة
جامعة عين شمس - كلية الطب - امراض الغدد الصماء والايض
الفهرس
Only 14 pages are availabe for public view

from 146

from 146

Abstract

• Type 1 diabetes mellitus (T1DM) is an inflammatory disease of the pancreatic islets that results in absolute insulin deficiency and the consecutive hyperglycemia due to immune-mediated beta cell destruction.
• Although β cell death is the pathophysiological core of T1DM, recent data suggest that the disease associated metabolic disturbances represent a common feature of autoimmunity and insulin resistance (IR) caused by adipocyte derived pro-inflammatory factors, chronic activation of innate immune system, and low-grade inflammation.
• Out of recently identified adipocytokines, dipeptidyl peptidase-4 (DPP-4) and tumor necrosis factor alpha are important in the pathogenesis of IR in type 1 Diabetes.
• Our study aimed to focus on the relationship between Serum DPP-4 enzyme, TNFα and Insulin sensitivity measured by eGDR in type 1 diabetes mellitus patients.
• Our results found out that the group with lower insulin sensitivity (eGDR ≤ 6.125), had higher levels of DPP-4, WHR, HbA1c, TNFα, in comparison to the second group (eGDR ≥6.125).
• Males in our study had lower Insulin sensitivity than females, but higher TNFα, DPP-4, HbA1c than females
• This study proved that Insulin sensitivity was negatively related to DPP-4.
• TNF α, HbA1c, WHR
• We found out that TNF α was positively significantly related to DPP-4, HbA1c, WHR, but had a negative significant relationship with Insulin sensitivity.
• Our study proved that serum level of DPP-4 had a highly significant positive relationship with WHR, TNFα, HbA1c and negative relationship with eGDR.