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العنوان
Impulsivity as a Clinical Marker for Bipolar Affective Disorder /
المؤلف
Farrag, Wafaa Abdelhalim.
هيئة الاعداد
باحث / وفاء عبدالحليم فراج
مشرف / عبد الناصر محمود عمر
مشرف / أميرة نسيب البطراوي
مشرف / ولاء محمد صبري
مشرف / حسين أحمد الخولي
تاريخ النشر
2018.
عدد الصفحات
182 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الطب النفسي والصحة العقلية
تاريخ الإجازة
1/1/2018
مكان الإجازة
جامعة عين شمس - كلية الطب - المخ والاعصاب والطب النفسي
الفهرس
Only 14 pages are availabe for public view

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from 182

Abstract

Bipolar disorder is one of the world’s 10 most disabling conditions, taking away years of healthy functioning from individuals who have the illness. Impulsivity considered an integral part of bipolar disorder with potential consequences of substance abuse, suicidal behavior, and other serious behavioral problems.
Impulsivity has interacting state- and trait-like characteristics. Trait impulsivity, as measured by the Barratt Impulsiveness Scale (BIS-11), is increased in bipolar disorder, even when patients are euthymic.
Several studies reported that unaffected first-degree relatives of BD patients committed more response inhibition errors than controls in tasks measuring impulsive behavior. Further, they also displayed more trait impulsivity as measured on the BIS-11. In addition, Bora et al. demonstrated in their meta-analysis that deficient response inhibition is the most prominent endophenotype of BD compared to several other executive functions.
So, we hypothesized that both euthymic individuals with bipolar disorder and their clinically unaffected first-degree relatives would have higher levels of trait impulsivity compared to healthy subjects.
The aim of the current study was to measure impulsivity in both BD euthymic patients and in healthy first-degree relatives of BD patients and compare it to controls. And to assess the functional implications of impulsiveness, on psychosocial functioning and in bipolar disorder patients, their first-degree relatives, and controls.
Participants involved in the study will be subjected to:
1- Informed consent: A written consent will be obtained from them after explaining the objectives of the study.
2- Full neuropsychiatric history and examination for patients with BD using psychiatric sheet of Institute of Psychiatry Ain Shams University.
3- Arabic version of Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID-I): for clinical assessment and diagnosis of bipolar affective disorder and exclude other psychiatric disorders.
4- Arabic version of Structured Clinical Interview for DSM-IV-TR Axis II Disorders (SCID-II) to exclude personality disorders.
5- Arabic version of Hamilton Rating Scale for Depression to exclude depressive episode in cases of BAD.
6- Young Mania Rating Scale to exclude manic episodes in cases of BAD
7- Arabic version of Barratt Impulsiveness Scale (BIS) to measure of impulsiveness in bipolar affective disorder patients, healthy relatives and controls.
8- Arabic version of Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist Instructions to exclude Adult ADHD in both cases and controls.
9- A global assessment of functioning (GAF) score was determined for each subject by DSM–IV criteria.
The main findings of this study were:
Cases have higher overall impulsivity in comparison to relatives and controls, and relatives have significantly higher (BIS) total, motor and non-planning impulsivity than controls.
Our findings suggest that impulsivity measured by BIS-11, may be a potentially valuable candidate endophenotype for bipolar disorder as it’s state independent and manifests in patient’s relatives more than general population.
The Global Assessment of Function (GAF) scores of the study sample results reveal that cases have more disturbed GAF than relatives. While investigating predictors of impulsivity, family history of psychiatric illness appeared to be a significant predictor of increasing impulsivity in cases group, on the other hand, history of violence and history of drug use are significant predictors of increasing impulsivity in relatives’ group, while unemployment is significant predictor of increasing impulsivity in control group.