الفهرس 
CHRONIC VENOUS INSUFFICIENCYOnly 14 pages are availabe for public view
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Abstract
Platelet-rich plasma (PRP) is a volume of autologous
plasma that has a platelet concentration above baseline.
The use of Platelet-Rich Plasma (PRP) in medicine has
become increasingly more widespread during the last decade.
The use of PRP in medicine is based on the fact that platelets
contain many growth factors in their alpha granules. These
factors have a well-known role in the process of tissue repair.
Venous ulcers are the most common form of leg ulcers which
has a significant impact on quality of life and work
productivity. Conventional therapies are not able to provide
necessary growth factors that can modulate healing processes.
Chronic non healing ulcers lack the necessary growth factors
(GFs) and hence do not heal well.
The present study was conducted to compare the clinical
efficacy of platelet rich plasma in the management of chronic
venous ulcers (as regard the time of complete ulcer healing or
shrinkage in size) with the conventional methods of treatment
of venous ulcers (compression + dressing).
To achieve this aim this study was conducted on 40 patients
with chronic lower limb venous ulcer, they were divided into 2
equal groups with no statistically significant as regard personal and medical data, etiology of ulcer and as regard length, width
and size of the ulcer before the start of treatment.
group A (cases): included 20 patients with chronic
venous ulcer who were treated with platelet rich plasma -
topically applied to the ulcer then dressed by vasline gauze and
compressed by graduated elastic stocking- for 6 sessions with
one week interval between sessions.
group B (control): included 20 patients with chronic
venous ulcer who were managed conservatively by
compression using graduated elastic stockings below the knee
and dressing using saline and vasline guaze weekly for 6 weeks.
Results of the study showed marked improvement in
patients treated with PRP when compared to patients treated
conservatively who showed mild improvement after 6 weeks on
conventional treatment, with statistically significant difference
between cases and controls groups as regard length, width and
size of the ulcers at the end of treatment after 6 weeks, adding
more evidence to treatment efficacy with PRP when compared
with the traditional methods.
Results also showed that the percentage of complete
ulcer healing in cases group was much higher with highly
statistically significant difference when compared to control
group.There were no side effects and there was a decrease in
pain associated with the ulcers. Results of this work showed
that DM, was an independent factor affecting mean change in
size of the ulcer and impairing healing.