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العنوان
Study of The Effect of Copper Complex on Apoptotic Pathway in Triple Negative Breast Cancer /
الناشر
Marihan Ahmed Awad Helal,
المؤلف
Helal, Marihan Ahmed Awad.
هيئة الاعداد
باحث / Marihan Ahmed Awad Helal
مشرف / ELShahat Abou Mosalam Toson
مشرف / Mohamed Ahmed Abdel-Mohsen
مناقش / Omali Yossef Abdelgalil Elkhawaga
الموضوع
السرطان - امراض. الثدي - سرطان. الاورام الخبيثه.
تاريخ النشر
2018.
عدد الصفحات
248 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Biochemistry
تاريخ الإجازة
31/12/2018
مكان الإجازة
جامعة دمياط - كلية العلوم - Chemistry
الفهرس
Only 14 pages are availabe for public view

from 282

from 282

Abstract

Triple-negative breast cancer (TNBC) is an advanced multi-drug resistance breast cancer which affect majority of women worldwide. TNBC is characterized by the lack of estrogens receptor (ER), progesterone receptor (PR) expression, and normal human epidermal growth factor receptor 2 (HER2). In this context, Doxorubicin (DOX) therapy acting on DNA and free radical generation and apoptosis induction, is the best known anthracycline and the cornerstone drug in the treatment of TNBC. Despite being the primary treatment used for TNBC, DOX has only partial efficacy, and its cardiotoxicity is a limiting factor. Furthermore, development of drug resistance to DOX via mammalian target of rapamycin (mTOR) pathway is a major challenge undermining successful cancer treatment. Interestingly, Torin 1 is a potent and selective inhibitor of mTOR kinase, which mimics cellular starvation by blocking signals required for cell growth and proliferation in cancer cells and activation of cell death pathways. In conclusion, in TNBC treatment, a need is felt to find alternative drugs to synthetic drugs, which could reduce and repair the deleterious effects of doxorubicin-induced DNA damage. So, various combinations were done to be effective to reduce the toxic doses of DOX and then its side effects. In this study, the following combinations were designed as the combination of DOX with either CNC or Torin1 and the combination of CNC with Torin1. All preformed combinations were an attempt for a novel strategy for TNBC treatment where it was consisted of one pro-apoptotic drug and the other drug affect cell resistance. The data of present study may lead to the suggestion that CNC can be considered as a promising anticancer agent for TNBC through several suggestive mechanisms including anti-proliferative, pro-apoptotic, and free radical-dependant death mechanisms. As a result, this study introduce more than strategy for TNBC treatment via various mechanisms.