الفهرس 
Obesity and leptin hormoneOnly 14 pages are availabe for public view
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Abstract
Introduction: Obesity has reached epidemic proportions in many countries around
the world. One mechanism by which obesity may contribute to the pathogenesis of
T2DM is that the increased flux of FFAs from lipolysis in visceral adipose tissue causes
insulin resistance and impairs pancreatic β-cell function. Tea is one of the most popular
beverages consumed worldwide. Tea, from the plant Camellia sinensis, is consumed in
different parts of the world as green, black, or oolong tea. Catechins are the main
compounds in green tea reduce the risk of a variety of diseases. Green tea catechins affect
lipid metabolism by different pathways and prevent the appearance of atherosclerotic
plaque green tea intake decreases the absorption of triglycerides and cholesterol and these
findings are in accordance with the fact that fat excretion increases and could have a
beneficial effect against lipid and glucose metabolism disorders implicated in years,
interest has increased in using natural products for pharmacological purposes, as a form
of complementary or replacement therapy as Inulin, a group of dietary fibers, is reported
to improve the metabolic disorders. Inulin decreased serum triglycerides and abdominal
fat deposition and may have unique metabolic effects that are of particular benefit to
people at risk of diabetes. Material and Methods: The study was conducted on 08 male
albino rats divided into two main groups, the first main group 40 rats were infected with
Diabetes were divided into 8 sub-groups fed on basal diet plus (15 ml green tea + 0.2
or0.5 mg catechin, 15ml green tea + 14 or 18 gm inulin or its combination). Likewise,
has fueled second major group (infected with obesity and feed high fat diet). In first main
group diabetic rats results revealed that, all treated rats resulted in significant increase
(P<0.01) of feed intake, body weight gain %, Adiponectin and weight of organs% than
positive control group, while total Cholesterol, triglyceride, LDL-c , VLDL-c , HDL\LDL
ratio ,Leptin and blood glucose was decreased.
In second main group Obese Rats results revealed that, all treated rats with15 ml
enriched with catechin and inulin resulted in significant decrease (P<0.01) of feed intake,
body weight gain %, Leptin total Cholesterol, triglyceride, LDL-c, VLDL-c, HDL\LDL
ratio and blood glucose than positive control group (Untreated fed on high fat diet) while
Adiponectin and HDL-c was increased while There were no significant differences
Relative weight of organs%. In conclusion, green tea catechin and inulin appears to
improve not only hyperglycemia but also dyslipidemia.