الفهرس 
EPIDEMIOLOGYOnly 14 pages are availabe for public view
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Abstract
Head and neck cancer represents more than 550,000 cases and 380,000 deaths every year worldwide.
Previous hospital-based studies from Egypt showed that HNC constitutes about 17-20% of all malignancies.
The main risk factors include tobacco and alcohol use and HPV virus infection.
Most of patients present with late stage disease where cure rates reach only 30%.
Studies have shown that HNSCC are heterogeneous tumors which made it difficult to accurately predicts prognosis, treatment planning and identification of the causative cancer genes.
HIF-1α prognostic role in head and neck squamous cell carcinoma has been studied in several clinical trials.
Contradicting data has been published about the prognostic role of HIF-1α between being a poor prognostic marker versus being a good prognostic marker.
In the current study we did not find any statistical significance between response to treatment, PFS or OS and HIF-1α expression.
We also found a significant correlation between HIF-1 α and the T stage of the tumor, yet, no other correlation was found with other clinicopathological features.
The prognostic role of BCL-2 has also been studied in head and neck squamous cell carcinoma, but the published data are very contradicting.
In the present study, BCL-2 expression was not found to be statistically significant when correlated to response to treatment, PFS or OS.
We also did not find a significant correlation between BCL-2 and the clinicopathological features.
Regarding the relation between the clinicopathological features of the tumor and PFS and OS, we only found a statistically significant correlation between the T stage of the tumor and the patients’ PFS and OS.