الفهرس 
Acute Myeloid Leukemia
Gastrointestinal complications of HSCTOnly 14 pages are availabe for public view
 |  | from | 229 |  |  |
| | | from | 229 | | |
Abstract
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for acute leukemia patients.
Despite progress in immunosuppressive and antiviral therapy, acute graft-versus-host disease (aGVHD) and cytomegalovirus (CMV) infection remain important complications after allogeneic HSCT. GVHD and CMV replication are pathogenetically associated: multiple studies show that GVHD and its treatment put patients at risk for CMV replication. In contrast, the role of CMV replication as a cause of GVHD is controversial.
In conclusion the use of CMV prophylaxis routinely with new agents with lower toxicity, especially in patients at high risk of CMV replication, might reduce the incidence of CMV replications, reducing so the morbidity and mortality, and according to some studies may also reduce the incidence of aGVHD and its related morbidity and mortality.