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Bone metastasis is the most common tumor affecting bone the skeleton is the third common site for metastasis after the lung and liver.
Incidences varied by tumor type with prostate cancer patients were at highest risk (18% – 29%) followed by lung, renal and breast cancer.
Bone metastasis could cause pain, hypercalcemia, bone fractures and spinal cord compression.
Bone metastasis could be osteolytic or osteoblastic and mixed type.
As regard pain there are different types and different causes for pain in cancer patients which was assessed by including numerical rating score, visual analogue scale, categorical scale, pictorial scale.
Management of pain could be achieved by pharmacological, adjunct, surgical, radiation and non-pharmacological ways.
As regard radiotherapy in treatment of painful bone metastasis by 3D-conformal, intensity modulated radiation therapy (IMRT), Stereotactic body radiation therapy (SBRT), or stereotactic ablative body radiotherapy (SABR), Cyberknife, Tomotherapy and Radioactive isotopes.
In our study we compared single fraction radiotherapy and multiple fraction radiotherapy in palliating pain and prevention of skeletal related events.
Results of our study found equivalency and effectiveness of single and multiple fraction arms in terms of palliating pain and prevention of skeletal events.