الفهرس 
EPILEPSY
Criteria of refractorinessOnly 14 pages are availabe for public view
 |  | from | 173 |  |  |
| | | from | 173 | | |
Abstract
The most accepted definition for drug resistant epilepsy is
failure of adequate trials of 2 tolerated and appropriately
chosen and used anti-epileptic drugs (AED) schedules whether
as monotherapies or in combination) to achieve sustained
seizure freedom.
Ketogenic diet is a high-fat, low-carbohydrate, and
adequate-protein diet well-established as treatment option for
drug resistant childhood epilepsies.
Our aim of the current study is to evaluate serum
Selenium levels in children receiving KD treatment for
intractable seizures for 6 months duration and to verify the
efficacy of KD on oxidative stress by evaluation serum MDA
and TAC levels.
The present study included 90 infants and children with
age range from 6 months to 6 years they were sub-divided into
3 groups
group I: Thirty patients with drug resistant epilepsy
under pharmacological treatments only,
group II: Thirty patients with drug resistant epilepsy
under treatment with KD for 6 months and other
pharmacological treatments group III: Thirty age and sex matched healthy infants
and children served as controls.
All subjects were not receiving Se containing or
antioxidant drugs. Furthermore, all subjects have no chronic or
systemic diseases (e.g. cardiac, hepatic, or renal diseases).
There was no statistically significant difference between the
ages and gender of the groups in the study.
All subjects were recruited from Children Hospital Ain
Shams University Hospital during the period May 2017 to
January 2018.
All subjects in the present study was evaluated through
full medical history stressing on frequency and severity of
seizures for patients, clinical examination with emphasis on
neurological examination, anthropometric measures and
symptoms of selenium deficiency, and finally laboratory
investigations evaluating serum Se, MDA and TAC.
As regards frequency and severity of seizures; they were
significantly lower in group II receiving KD as a treatment than
group I on pharmacological treatment only.
Regarding Se levels was noted to be lower in overall
epileptic patients in comparison to controls but it was markedly
lower in the KD group.For serum MDA levels; it was found to be higher in
overall epileptic patients in comparison to controls with a lower
value among group of patients receiving treatment with KD
compared to refractory epileptic patients on pharmacological
treatment only.
Regarding Serum TAC levels; it was found to be lower
in overall epileptic patients in comparison to controls with a
higher value among group of patients receiving treatment with
KD compared to refractory epileptic patients on
pharmacological treatment only.
In summary, KD is an effective treatment for refractory
epilepsy for its anti-epileptic mechanism. It also may exert antioxidant
effects. The nutrient content of KD may not meet the
RDA for Se and so this should be taken in consideration for
supplementation of minerals in adequate amounts.