الفهرس 
Encephalitis/Meningitis in Infants and ChildrenOnly 14 pages are availabe for public view
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Abstract
A
cute encephalitis/encephalopathy (AEE) is a devastating cause of severe neurodevelopmental sequelae or death in children (Tsukahara et al., 2013).
Morbidity assessments are becoming a more important aspect of pediatric outcomes research especially in studies with a significant risk for decreased functional status due to neurologic processes (Pollack et al., 2014).
This study was conducted to evaluate Neuro-developmental Outcome of Infants and Children with acute central nervous system infections.
This study was a prospective case-control study that included 30infants and children whose age ranged from 7 to 36 months old with previous normal neurodevelopmental progress during the period between June, 2016 till august,2017of 15 months time frame.
They comprised 2 groups group one included twenty infants and children presenting with acute central nervous system infection. recruited from the out patient clinic and the ER of the Children’s Hospital, Faculty of Medicine, Ain Shams University.
Patients’ group was classified into 2groups according to bacterial meningitis score system (Nigrovic et al., 2002). group (A) meningetic group which included 11 patients 7 males (63.6%), 4 females (36.4%), group (B) nonmeningetic group included 9 patients 5 males (55.6%), 4 females (44.4%).
group two Ten apparently normal infants and children of age and sex matching to the cases recruited from siblings of children attending the outpatient clinic with normal neurodevelopmental progress it included 4 males (40%), 6 females (60%).
In our study regarding the comparison between the Bayley composite scores of the patients after one month of discharge from hospital and the control infants. All the patients’ composite scores were significantly lower than the control scores.
The neurodevelopmental comparison between the meningetic and non-meningetic group.
We found apparent decrease in the composite scores among non-meningetic group compared the meningetic group. However the only statistically significant decrease in the language composite score in non-meningetic group compared meningetic group p= (0.017).
Our study showed that Survivors of CNS infections are at risk of developing severe neurological sequelae.
Among the survivors the proportion that recover their previous work capacity is not fully known, but is an important indicator of complete rehabilitation.