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Background: Lipoxin A4 is a potent anti-inflammatory and several lipoxin forming multicellular interactions occur during strenuous
Aim of the study: to evaluate diagnostic value of lipoxin A4 as a biomarker of exercise induced asthma
Subjects and methods: This cross sectional study was conducted on forty-five asthmatic children divided in two groups; EIA group: 25 children with history of exercise-induced symptoms of asthma confirmed by spirometry, Non EIA group: 20 patients who did not have history of exercise induced symptoms of asthma. Forty-five apparently healthy children were included as a control group with no history of asthma or atopic conditions. Their age and sex were matched with the patients group. For all patients, pulmonary function tests were done before and after a free running test using portable spiromometery. Serum levels of lipoxin A4 were estimated for patients (after exercise) and controls using ELISA
Results: A significant difference was detected between the levels of lipoxin A4 in EIA and control groups (p value 0.000). There was significant difference between Non EIA and control groups regarding the level of lipoxin A4 with (P value 0.000). The mean level of lipoxin A4 in EIA patients was lower than that of Non EIA patients; however, the difference was statistically insignificant (P value 0.973). Conclusion: Lipoxin A4 is a promising anti-inflammatory factor in management of asthma.